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Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Eroglu C, et al. Among authors: green em. Cell. 2009 Oct 16;139(2):380-92. doi: 10.1016/j.cell.2009.09.025. Epub 2009 Oct 8. Cell. 2009. PMID: 19818485 Free PMC article.
Calcium channels light up.
Green E, Dolmetsch RE. Green E, et al. Nat Chem Biol. 2007 Jul;3(7):369-70. doi: 10.1038/nchembio0707-369. Nat Chem Biol. 2007. PMID: 17576420 No abstract available.
First-in-Human Evaluation of Safety, Pharmacokinetics and Muscle Glycogen Lowering of a Novel Glycogen Synthase 1 Inhibitor for the Treatment of Pompe Disease.
Ullman JC, Dick RA, Linzner D, Minga T, Tep S, Satterfield TF, Xi Y, Beattie DT, Marmon T, Neutel JM, Chung B, Leeds JM, Noonberg SB, Green EM, Bernstein HS. Ullman JC, et al. Among authors: green em. Clin Pharmacol Ther. 2024 Dec;116(6):1580-1592. doi: 10.1002/cpt.3470. Epub 2024 Oct 22. Clin Pharmacol Ther. 2024. PMID: 39439155 Clinical Trial.
Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.
Gaspar RC, Sakuma I, Nasiri A, Hubbard BT, LaMoia TE, Leitner BP, Tep S, Xi Y, Green EM, Ullman JC, Petersen KF, Shulman GI. Gaspar RC, et al. Among authors: green em. Am J Physiol Endocrinol Metab. 2024 Oct 1;327(4):E524-E532. doi: 10.1152/ajpendo.00175.2024. Epub 2024 Aug 22. Am J Physiol Endocrinol Metab. 2024. PMID: 39171753
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Ullman JC, Mellem KT, Xi Y, Ramanan V, Merritt H, Choy R, Gujral T, Young LEA, Blake K, Tep S, Homburger JR, O'Regan A, Ganesh S, Wong P, Satterfield TF, Lin B, Situ E, Yu C, Espanol B, Sarwaikar R, Fastman N, Tzitzilonis C, Lee P, Reiton D, Morton V, Santiago P, Won W, Powers H, Cummings BB, Hoek M, Graham RR, Chandriani SJ, Bainer R, DePaoli-Roach AA, Roach PJ, Hurley TD, Sun RC, Gentry MS, Sinz C, Dick RA, Noonberg SB, Beattie DT, Morgans DJ Jr, Green EM. Ullman JC, et al. Among authors: green em. Sci Transl Med. 2024 Jan 17;16(730):eadf1691. doi: 10.1126/scitranslmed.adf1691. Epub 2024 Jan 17. Sci Transl Med. 2024. PMID: 38232139
Severe polycystic liver disease in a cat.
King EM, Pappano M, Lorbach SK, Green EM, Parker VJ, Schreeg ME. King EM, et al. Among authors: green em. JFMS Open Rep. 2023 Dec 24;9(2):20551169231216859. doi: 10.1177/20551169231216859. eCollection 2023 Jul-Dec. JFMS Open Rep. 2023. PMID: 38146394 Free PMC article.
179 results