Hirokawa T - Search Results

1

G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer.

Iida K, Tera M, Hirokawa T, Shin-ya K, Nagasawa K. Iida K, et al. Among authors: hirokawa t. Chem Commun (Camb). 2009 Nov 14;(42):6481-3. doi: 10.1039/b910242f. Epub 2009 Sep 14. Chem Commun (Camb). 2009. PMID: 19841816

2

JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.

Izumikawa M, Hashimoto J, Hirokawa T, Sugimoto S, Kato T, Takagi M, Shin-Ya K. Izumikawa M, et al. Among authors: hirokawa t. J Nat Prod. 2010 Apr 23;73(4):628-31. doi: 10.1021/np900788e. J Nat Prod. 2010. PMID: 20180542

3

Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.

Iida K, Tera M, Hirokawa T, Shin-Ya K, Nagasawa K. Iida K, et al. Among authors: hirokawa t. J Nucleic Acids. 2010;2010:217627. doi: 10.4061/2010/217627. Epub 2010 May 24. J Nucleic Acids. 2010. PMID: 20700415 Free PMC article.

4

Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.

Shinohara R, Akimoto T, Iwamoto O, Hirokawa T, Yotsu-Yamashita M, Yamaoka K, Nagasawa K. Shinohara R, et al. Among authors: hirokawa t. Chemistry. 2011 Oct 17;17(43):12144-52. doi: 10.1002/chem.201101058. Epub 2011 Sep 16. Chemistry. 2011. PMID: 21922571

5

Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.

Hosoya T, Hirokawa T, Takagi M, Shin-ya K. Hosoya T, et al. Among authors: hirokawa t. J Nat Prod. 2012 Feb 24;75(2):285-9. doi: 10.1021/np200843k. Epub 2012 Jan 25. J Nat Prod. 2012. PMID: 22276693

6

Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity.

Abe J, Nagai Y, Higashikuni R, Iida K, Hirokawa T, Nagai H, Kominato K, Tsuchida T, Hirata M, Inada M, Miyaura C, Nagasawa K. Abe J, et al. Among authors: hirokawa t. Org Biomol Chem. 2012 Oct 14;10(38):7826-39. doi: 10.1039/c2ob26017d. Org Biomol Chem. 2012. PMID: 22930071

7

Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.

Fuse S, Inaba K, Takagi M, Tanaka M, Hirokawa T, Johmoto K, Uekusa H, Shin-Ya K, Takahashi T, Doi T. Fuse S, et al. Among authors: hirokawa t. Eur J Med Chem. 2013 Aug;66:180-4. doi: 10.1016/j.ejmech.2013.05.030. Epub 2013 Jun 3. Eur J Med Chem. 2013. PMID: 23792765

8

Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

Akimoto T, Masuda A, Yotsu-Yamashita M, Hirokawa T, Nagasawa K. Akimoto T, et al. Among authors: hirokawa t. Org Biomol Chem. 2013 Oct 14;11(38):6642-9. doi: 10.1039/c3ob41398e. Epub 2013 Aug 30. Org Biomol Chem. 2013. PMID: 23989458

9

Design and synthesis of a berberine dimer: a fluorescent ligand with high affinity towards G-quadruplexes.

Tera M, Hirokawa T, Okabe S, Sugahara K, Seimiya H, Shimamoto K. Tera M, et al. Among authors: hirokawa t. Chemistry. 2015 Oct 5;21(41):14519-28. doi: 10.1002/chem.201501693. Epub 2015 Aug 13. Chemistry. 2015. PMID: 26272465

10

Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA.

Sakuma M, Ma Y, Tsushima Y, Iida K, Hirokawa T, Nagasawa K. Sakuma M, et al. Among authors: hirokawa t. Org Biomol Chem. 2016 Jun 14;14(22):5109-16. doi: 10.1039/c6ob00437g. Epub 2016 May 16. Org Biomol Chem. 2016. PMID: 27181296

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