Monti D - Search Results

1

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.

Coghi P, Basilico N, Taramelli D, Chan WC, Haynes RK, Monti D. Coghi P, et al. Among authors: monti d. ChemMedChem. 2009 Dec;4(12):2045-53. doi: 10.1002/cmdc.200900342. ChemMedChem. 2009. PMID: 19844934

2

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates.

Haynes RK, Chan WC, Lung CM, Uhlemann AC, Eckstein U, Taramelli D, Parapini S, Monti D, Krishna S. Haynes RK, et al. Among authors: monti d. ChemMedChem. 2007 Oct;2(10):1480-97. doi: 10.1002/cmdc.200700108. ChemMedChem. 2007. PMID: 17768732 Free article.

3

A combinatorial approach to 2,4,6-trisubstituted triazines with potent antimalarial activity: combining conventional synthesis and microwave-assistance.

Melato S, Prosperi D, Coghi P, Basilico N, Monti D. Melato S, et al. Among authors: monti d. ChemMedChem. 2008 Jun;3(6):873-6. doi: 10.1002/cmdc.200700344. ChemMedChem. 2008. PMID: 18297663 No abstract available.

4

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action.

Haynes RK, Chan WC, Wong HN, Li KY, Wu WK, Fan KM, Sung HH, Williams ID, Prosperi D, Melato S, Coghi P, Monti D. Haynes RK, et al. Among authors: monti d. ChemMedChem. 2010 Aug 2;5(8):1282-99. doi: 10.1002/cmdc.201000225. ChemMedChem. 2010. PMID: 20629071

5

Does chloroquine really act through oxidative stress?

Monti D, Basilico N, Parapini S, Pasini E, Olliaro P, Taramelli D. Monti D, et al. FEBS Lett. 2002 Jul 3;522(1-3):3-5. doi: 10.1016/s0014-5793(02)02881-8. FEBS Lett. 2002. PMID: 12095608 Free article.

6

Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.

Parapini S, Basilico N, Mondani M, Olliaro P, Taramelli D, Monti D. Parapini S, et al. Among authors: monti d. FEBS Lett. 2004 Sep 24;575(1-3):91-4. doi: 10.1016/j.febslet.2004.08.039. FEBS Lett. 2004. PMID: 15388339 Free article.

7

Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.

Haynes RK, Cheu KW, Tang MM, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. Among authors: monti d. ChemMedChem. 2011 Feb 7;6(2):279-91. doi: 10.1002/cmdc.201000508. Epub 2010 Dec 23. ChemMedChem. 2011. PMID: 21275052

8

A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine.

Haynes RK, Cheu KW, Li KY, Tang MM, Wong HN, Chen MJ, Guo ZF, Guo ZH, Coghi P, Monti D. Haynes RK, et al. Among authors: monti d. ChemMedChem. 2011 Sep 5;6(9):1603-15. doi: 10.1002/cmdc.201100184. Epub 2011 Jul 11. ChemMedChem. 2011. PMID: 21994127

9

Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.

Haynes RK, Cheu KW, Chan HW, Wong HN, Li KY, Tang MM, Chen MJ, Guo ZF, Guo ZH, Sinniah K, Witte AB, Coghi P, Monti D. Haynes RK, et al. Among authors: monti d. ChemMedChem. 2012 Dec;7(12):2204-26. doi: 10.1002/cmdc.201200383. Epub 2012 Oct 30. ChemMedChem. 2012. PMID: 23112085

10

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D. Haynes RK, et al. Among authors: monti d. Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708. Infect Disord Drug Targets. 2013. PMID: 24304352 Review.

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