Clarkson BD - Search Results

1

Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance.

Guo T, Hajdu M, Agaram NP, Shinoda H, Veach D, Clarkson BD, Maki RG, Singer S, Dematteo RP, Besmer P, Antonescu CR. Guo T, et al. Among authors: clarkson bd. Clin Cancer Res. 2009 Nov 15;15(22):6862-70. doi: 10.1158/1078-0432.CCR-09-1315. Epub 2009 Oct 27. Clin Cancer Res. 2009. PMID: 19861442 Free PMC article.

2

L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition.

Antonescu CR, Busam KJ, Francone TD, Wong GC, Guo T, Agaram NP, Besmer P, Jungbluth A, Gimbel M, Chen CT, Veach D, Clarkson BD, Paty PB, Weiser MR. Antonescu CR, et al. Among authors: clarkson bd. Int J Cancer. 2007 Jul 15;121(2):257-64. doi: 10.1002/ijc.22681. Int J Cancer. 2007. PMID: 17372901

3

Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor.

Guo T, Agaram NP, Wong GC, Hom G, D'Adamo D, Maki RG, Schwartz GK, Veach D, Clarkson BD, Singer S, DeMatteo RP, Besmer P, Antonescu CR. Guo T, et al. Among authors: clarkson bd. Clin Cancer Res. 2007 Aug 15;13(16):4874-81. doi: 10.1158/1078-0432.CCR-07-0484. Clin Cancer Res. 2007. PMID: 17699867

4

Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.

Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P. Rossi F, et al. Mol Cancer Res. 2010 Sep;8(9):1271-83. doi: 10.1158/1541-7786.MCR-10-0065. Epub 2010 Aug 24. Mol Cancer Res. 2010. PMID: 20736294 Free PMC article.

5

Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.

Wisniewski D, Lambek CL, Liu C, Strife A, Veach DR, Nagar B, Young MA, Schindler T, Bornmann WG, Bertino JR, Kuriyan J, Clarkson B. Wisniewski D, et al. Cancer Res. 2002 Aug 1;62(15):4244-55. Cancer Res. 2002. PMID: 12154026

6

Synthesis and biological evaluation of a fluorine-18 derivative of dasatinib.

Veach DR, Namavari M, Pillarsetty N, Santos EB, Beresten-Kochetkov T, Lambek C, Punzalan BJ, Antczak C, Smith-Jones PM, Djaballah H, Clarkson B, Larson SM. Veach DR, et al. J Med Chem. 2007 Nov 15;50(23):5853-7. doi: 10.1021/jm070342g. Epub 2007 Oct 23. J Med Chem. 2007. PMID: 17956080

7

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.

Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF. Gao SP, et al. J Clin Invest. 2007 Dec;117(12):3846-56. doi: 10.1172/JCI31871. J Clin Invest. 2007. PMID: 18060032 Free PMC article.

8

Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors.

Antczak C, Veach DR, Ramirez CN, Minchenko MA, Shum D, Calder PA, Frattini MG, Clarkson B, Djaballah H. Antczak C, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. doi: 10.1016/j.bmcl.2009.10.085. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19889540 Free PMC article.

9

Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors.

von Bubnoff N, Veach DR, Miller WT, Li W, Sänger J, Peschel C, Bornmann WG, Clarkson B, Duyster J. von Bubnoff N, et al. Cancer Res. 2003 Oct 1;63(19):6395-404. Cancer Res. 2003. PMID: 14559829

10

Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.

Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R. Deng X, et al. Nat Genet. 2004 Aug;36(8):906-12. doi: 10.1038/ng1396. Epub 2004 Jul 25. Nat Genet. 2004. PMID: 15273685

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