Yang S - Search Results

1

Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.

Tercel M, Atwell GJ, Yang S, Stevenson RJ, Botting KJ, Boyd M, Smith E, Anderson RF, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: yang s. J Med Chem. 2009 Nov 26;52(22):7258-72. doi: 10.1021/jm901202b. J Med Chem. 2009. PMID: 19877646

2

An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

Atwell GJ, Yang S, Denny WA. Atwell GJ, et al. Among authors: yang s. Eur J Med Chem. 2002 Oct;37(10):825-8. doi: 10.1016/s0223-5234(02)01406-x. Eur J Med Chem. 2002. PMID: 12446040

3

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA. Helsby NA, et al. Among authors: yang s. J Med Chem. 2004 Jun 3;47(12):3295-307. doi: 10.1021/jm0498699. J Med Chem. 2004. PMID: 15163209

4

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: yang s. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

5

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: yang s. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

6

Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.

Tercel M, Yang S, Atwell GJ, Smith E, Gu Y, Anderson RF, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: yang s. Bioorg Med Chem. 2010 Jul 15;18(14):4997-5006. doi: 10.1016/j.bmc.2010.06.001. Epub 2010 Jun 8. Bioorg Med Chem. 2010. PMID: 20580559

7

Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.

Tercel M, Atwell GJ, Yang S, Ashoorzadeh A, Stevenson RJ, Botting KJ, Gu Y, Mehta SY, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: yang s. Angew Chem Int Ed Engl. 2011 Mar 7;50(11):2606-9. doi: 10.1002/anie.201004456. Epub 2011 Feb 17. Angew Chem Int Ed Engl. 2011. PMID: 21370347 No abstract available.

8

Preparation and antitumour properties of the enantiomers of a hypoxia-selective nitro analogue of the duocarmycins.

Tercel M, Lee HH, Yang S, Liyanage HD, Mehta SY, Boyd PD, Jaiswal JK, Tan KL, Pruijn FB. Tercel M, et al. Among authors: yang s. ChemMedChem. 2011 Oct 4;6(10):1860-71. doi: 10.1002/cmdc.201100271. Epub 2011 Jul 26. ChemMedChem. 2011. PMID: 21793220

9

A new short synthesis of 3-substituted 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (amino-CBIs).

Yang S, Denny WA. Yang S, et al. J Org Chem. 2002 Dec 13;67(25):8958-61. doi: 10.1021/jo0263115. J Org Chem. 2002. PMID: 12467414

10

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR. Helsby NA, et al. Among authors: yang s. Chem Res Toxicol. 2003 Apr;16(4):469-78. doi: 10.1021/tx025662b. Chem Res Toxicol. 2003. PMID: 12703963

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