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Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.
Fickert P, Fuchsbichler A, Moustafa T, Wagner M, Zollner G, Halilbasic E, Stöger U, Arrese M, Pizarro M, Solís N, Carrasco G, Caligiuri A, Sombetzki M, Reisinger E, Tsybrovskyy O, Zatloukal K, Denk H, Jaeschke H, Pinzani M, Trauner M. Fickert P, et al. Among authors: pinzani m. Am J Pathol. 2009 Dec;175(6):2392-405. doi: 10.2353/ajpath.2009.090114. Epub 2009 Nov 12. Am J Pathol. 2009. PMID: 19910507 Free PMC article.
Induction of procollagen type I gene expression and synthesis in human hepatic stellate cells by 4-hydroxy-2,3-nonenal and other 4-hydroxy-2,3-alkenals is related to their molecular structure.
Parola M, Pinzani M, Casini A, Leonarduzzi G, Marra F, Caligiuri A, Ceni E, Biondi P, Poli G, Dianzani MU. Parola M, et al. Among authors: pinzani m. Biochem Biophys Res Commun. 1996 May 15;222(2):261-4. doi: 10.1006/bbrc.1996.0732. Biochem Biophys Res Commun. 1996. PMID: 8670193
321 results