Greiner C - Search Results

1

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: greiner c. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399

2

2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo.

Greiner C, Hörnig C, Rossi A, Pergola C, Zettl H, Schubert-Zsilavecz M, Steinhilber D, Sautebin L, Werz O. Greiner C, et al. Br J Pharmacol. 2011 Sep;164(2b):781-93. doi: 10.1111/j.1476-5381.2011.01451.x. Br J Pharmacol. 2011. PMID: 21506958 Free PMC article.

3

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: greiner c. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

4

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Greiner C, Zettl H, Koeberle A, Pergola C, Northoff H, Schubert-Zsilavecz M, Werz O. Greiner C, et al. Bioorg Med Chem. 2011 Jun 1;19(11):3394-401. doi: 10.1016/j.bmc.2011.04.034. Epub 2011 Apr 22. Bioorg Med Chem. 2011. PMID: 21570310

5

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, Syha I, Schubert-Zsilavecz M, Steinhilber D. Werz O, et al. Among authors: greiner c. J Med Chem. 2008 Sep 11;51(17):5449-53. doi: 10.1021/jm800588x. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710209

6

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes.

Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hörnig C, Steinhilber D, Schubert-Zsilavecz M, Werz O. Poeckel D, et al. Among authors: greiner c. Biochem Pharmacol. 2008 Jul 1;76(1):91-7. doi: 10.1016/j.bcp.2008.04.013. Epub 2008 May 1. Biochem Pharmacol. 2008. PMID: 18508031

7

Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways.

Poeckel D, Greiner C, Pergola C, Henkel A, Popescu L, Rau O, Schubert-Zsilavecz M, Werz O. Poeckel D, et al. Among authors: greiner c. Eur J Pharmacol. 2009 Oct 1;619(1-3):1-7. doi: 10.1016/j.ejphar.2009.08.014. Epub 2009 Aug 15. Eur J Pharmacol. 2009. PMID: 19686721

8

A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.

Hieke M, Greiner C, Thieme TM, Schubert-Zsilavecz M, Werz O, Zettl H. Hieke M, et al. Among authors: greiner c. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1329-33. doi: 10.1016/j.bmcl.2011.01.049. Epub 2011 Jan 18. Bioorg Med Chem Lett. 2011. PMID: 21310608

9

Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.

Hieke M, Greiner C, Dittrich M, Reisen F, Schneider G, Schubert-Zsilavecz M, Werz O. Hieke M, et al. Among authors: greiner c. J Med Chem. 2011 Jul 14;54(13):4490-507. doi: 10.1021/jm200092b. Epub 2011 Jun 8. J Med Chem. 2011. PMID: 21591611

10

SAR studies of acidic dual γ-secretase/PPARγ modulators.

Hieke M, Ness J, Steri R, Greiner C, Werz O, Schubert-Zsilavecz M, Weggen S, Zettl H. Hieke M, et al. Among authors: greiner c. Bioorg Med Chem. 2011 Sep 15;19(18):5372-82. doi: 10.1016/j.bmc.2011.08.003. Epub 2011 Aug 6. Bioorg Med Chem. 2011. PMID: 21873070

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