Durham HD - Search Results

1

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.

Kabashi E, Lin L, Tradewell ML, Dion PA, Bercier V, Bourgouin P, Rochefort D, Bel Hadj S, Durham HD, Vande Velde C, Rouleau GA, Drapeau P. Kabashi E, et al. Among authors: durham hd. Hum Mol Genet. 2010 Feb 15;19(4):671-83. doi: 10.1093/hmg/ddp534. Epub 2009 Dec 3. Hum Mol Genet. 2010. PMID: 19959528

2

Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis.

Kabashi E, Agar JN, Taylor DM, Minotti S, Durham HD. Kabashi E, et al. Among authors: durham hd. J Neurochem. 2004 Jun;89(6):1325-35. doi: 10.1111/j.1471-4159.2004.02453.x. J Neurochem. 2004. PMID: 15189335 Free article.

3

Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts.

Taylor DM, Kabashi E, Agar JN, Minotti S, Durham HD. Taylor DM, et al. Among authors: durham hd. Cell Stress Chaperones. 2005 Autumn;10(3):230-41. doi: 10.1379/csc-119r.1. Cell Stress Chaperones. 2005. PMID: 16184768 Free PMC article.

4

Failure of protein quality control in amyotrophic lateral sclerosis.

Kabashi E, Durham HD. Kabashi E, et al. Among authors: durham hd. Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1038-50. doi: 10.1016/j.bbadis.2006.06.006. Epub 2006 Jun 18. Biochim Biophys Acta. 2006. PMID: 16876390 Free article. Review.

5

Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis.

Taylor DM, Gibbs BF, Kabashi E, Minotti S, Durham HD, Agar JN. Taylor DM, et al. Among authors: durham hd. J Biol Chem. 2007 Jun 1;282(22):16329-35. doi: 10.1074/jbc.M610119200. Epub 2007 Mar 27. J Biol Chem. 2007. PMID: 17389599 Free article.

6

Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.

Taylor DM, Tradewell ML, Minotti S, Durham HD. Taylor DM, et al. Among authors: durham hd. Cell Stress Chaperones. 2007 Summer;12(2):151-62. doi: 10.1379/csc-254r.1. Cell Stress Chaperones. 2007. PMID: 17688194 Free PMC article.

7

Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.

Kabashi E, Agar JN, Hong Y, Taylor DM, Minotti S, Figlewicz DA, Durham HD. Kabashi E, et al. Among authors: durham hd. J Neurochem. 2008 Jun 1;105(6):2353-66. doi: 10.1111/j.1471-4159.2008.05317.x. J Neurochem. 2008. PMID: 18315558 Free article.

8

Mitochondrial and axonal abnormalities precede disruption of the neurofilament network in a model of charcot-marie-tooth disease type 2E and are prevented by heat shock proteins in a mutant-specific fashion.

Tradewell ML, Durham HD, Mushynski WE, Gentil BJ. Tradewell ML, et al. Among authors: durham hd. J Neuropathol Exp Neurol. 2009 Jun;68(6):642-52. doi: 10.1097/NEN.0b013e3181a5deeb. J Neuropathol Exp Neurol. 2009. PMID: 19458545

9

Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis.

Tradewell ML, Durham HD. Tradewell ML, et al. Among authors: durham hd. Neuroreport. 2010 Oct 27;21(15):976-9. doi: 10.1097/WNR.0b013e32833ddd45. Neuroreport. 2010. PMID: 20736867

10

Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention.

Tradewell ML, Cooper LA, Minotti S, Durham HD. Tradewell ML, et al. Among authors: durham hd. Neurobiol Dis. 2011 Jun;42(3):265-75. doi: 10.1016/j.nbd.2011.01.016. Epub 2011 Feb 3. Neurobiol Dis. 2011. PMID: 21296666

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