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SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. Yoshizaki T, et al. Among authors: olefsky jm. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8. Am J Physiol Endocrinol Metab. 2010. PMID: 19996381 Free PMC article.
Muscle-specific Pparg deletion causes insulin resistance.
Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. Hevener AL, et al. Nat Med. 2003 Dec;9(12):1491-7. doi: 10.1038/nm956. Epub 2003 Nov 16. Nat Med. 2003. PMID: 14625542
546 results