Kono K - Search Results

1

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].

Uto Y, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Ogata T, Deguchi T, Yamada M, Watanabe N, Konishi M, Kurikawa N, Takagi T, Wakimoto S, Kono K, Ohsumi J. Uto Y, et al. Among authors: kono k. Bioorg Med Chem Lett. 2010 Jan 15;20(2):746-54. doi: 10.1016/j.bmcl.2009.11.043. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 20006498

2

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.

Uto Y, Ogata T, Kiyotsuka Y, Miyazawa Y, Ueno Y, Kurata H, Deguchi T, Yamada M, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Konishi M, Kurikawa N, Kono K, Osumi J. Uto Y, et al. Among authors: kono k. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4159-66. doi: 10.1016/j.bmcl.2009.05.123. Epub 2009 Jun 6. Bioorg Med Chem Lett. 2009. PMID: 19541482

3

A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis.

Kurikawa N, Takagi T, Wakimoto S, Uto Y, Terashima H, Kono K, Ogata T, Ohsumi J. Kurikawa N, et al. Among authors: kono k. Biol Pharm Bull. 2013;36(2):259-67. doi: 10.1248/bpb.b12-00702. Biol Pharm Bull. 2013. PMID: 23370355 Free article.

4

A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives.

Kurata H, Suzuki S, Ohhata Y, Ikeda T, Hasegawa T, Kitayama K, Inaba T, Kono K, Kohama T. Kurata H, et al. Among authors: kono k. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1183-6. doi: 10.1016/j.bmcl.2003.12.063. Bioorg Med Chem Lett. 2004. PMID: 14980661

5

Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A.

Miyazawa Y, Yamaguchi T, Yamaguchi M, Tago K, Tamura A, Sugiyama D, Aburatani T, Nishizawa T, Kurikawa N, Kono K. Miyazawa Y, et al. Among authors: kono k. Bioorg Med Chem Lett. 2020 May 15;30(10):127105. doi: 10.1016/j.bmcl.2020.127105. Epub 2020 Mar 10. Bioorg Med Chem Lett. 2020. PMID: 32199732 Free article.

6

Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys.

Kitayama K, Nakai D, Kono K, van der Hoop AG, Kurata H, de Wit EC, Cohen LH, Inaba T, Kohama T. Kitayama K, et al. Among authors: kono k. Eur J Pharmacol. 2006 Jun 6;539(1-2):89-98. doi: 10.1016/j.ejphar.2006.04.005. Epub 2006 Apr 7. Eur J Pharmacol. 2006. PMID: 16687134

7

F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete.

Kono K, Tanaka M, Ogita T, Hosoya T, Kohama T. Kono K, et al. J Antibiot (Tokyo). 2000 May;53(5):459-66. doi: 10.7164/antibiotics.53.459. J Antibiot (Tokyo). 2000. PMID: 10908108 Free article.

8

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization.

Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T. Sugiura M, et al. Among authors: kono k. J Biol Chem. 2002 Jun 28;277(26):23294-300. doi: 10.1074/jbc.M201535200. Epub 2002 Apr 15. J Biol Chem. 2002. PMID: 11956206 Free article.

9

Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c.

Kono K, Sugiura M, Kohama T. Kono K, et al. J Antibiot (Tokyo). 2002 Jan;55(1):99-103. doi: 10.7164/antibiotics.55.99. J Antibiot (Tokyo). 2002. PMID: 11918073 Free article. No abstract available.

10

B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination.

Kono K, Tanaka M, Mizuno T, Kodama K, Ogita T, Kohama T. Kono K, et al. J Antibiot (Tokyo). 2000 Aug;53(8):753-8. doi: 10.7164/antibiotics.53.753. J Antibiot (Tokyo). 2000. PMID: 11079796 Free article.

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