MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.
Fu W, et al. Among authors: zhang m, zhang x, zhang y.
J Biol Chem. 2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25.
J Biol Chem. 2009.
PMID: 19321440
Free PMC article.