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The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.
Blasiak A, Truong ATL, Remus A, Hooi L, Seah SGK, Wang P, Chye H, Lim APC, Ng KT, Teo ST, Tan YJ, Allen DM, Chai LYA, Chng WJ, Lin RTP, Lye DCB, Wong JE, Tan GG, Chan CEZ, Chow EK, Ho D. Blasiak A, et al. Among authors: seah sgk. NPJ Digit Med. 2022 Jun 30;5(1):83. doi: 10.1038/s41746-022-00627-4. NPJ Digit Med. 2022. PMID: 35773329 Free PMC article.
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development.
Blasiak A, Lim JJ, Seah SGK, Kee T, Remus A, Chye H, Wong PS, Hooi L, Truong ATL, Le N, Chan CEZ, Desai R, Ding X, Hanson BJ, Chow EK, Ho D. Blasiak A, et al. Among authors: seah sgk. Bioeng Transl Med. 2020 Dec 1;6(1):e10196. doi: 10.1002/btm2.10196. eCollection 2021 Jan. Bioeng Transl Med. 2020. PMID: 33532594 Free PMC article.
Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly E, Young NJ, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. Asarnow D, et al. Among authors: seah sgk. Cell. 2021 Jun 10;184(12):3192-3204.e16. doi: 10.1016/j.cell.2021.04.033. Epub 2021 Apr 24. Cell. 2021. PMID: 33974910 Free PMC article.
Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.
Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI. Wang B, et al. Among authors: seah sgk. bioRxiv [Preprint]. 2020 Jul 15:2020.07.14.203414. doi: 10.1101/2020.07.14.203414. bioRxiv. 2020. PMID: 32699850 Free PMC article. Preprint.
First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.
Prativadibhayankaram VS, Lee LS, Lye D, Xiaoying X, Nellore R, Pendharkar V, Hentze H, Guan S, Ayers BJ, Seah SGK, Chye H, Talib NSN, Kaliaperumal N, Ong WY, Wong ZX, Au VB, Alok A, Connolly JE, Boyd-Kirkup JD, Ingram PJ, Hanson BJ, Ethirajulu K, O'Connell D, Chan CEZ. Prativadibhayankaram VS, et al. Among authors: seah sgk. Infect Dis Ther. 2022 Oct;11(5):1999-2015. doi: 10.1007/s40121-022-00681-1. Epub 2022 Sep 4. Infect Dis Ther. 2022. PMID: 36058990 Free PMC article.
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