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One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV. Denton PW, et al. Among authors: krisko jf. J Virol. 2011 Aug;85(15):7582-93. doi: 10.1128/JVI.00537-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593172 Free PMC article.
Generation of HIV latency in humanized BLT mice.
Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV. Denton PW, et al. Among authors: krisko jf. J Virol. 2012 Jan;86(1):630-4. doi: 10.1128/JVI.06120-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013053 Free PMC article.
HIV restriction by APOBEC3 in humanized mice.
Krisko JF, Martinez-Torres F, Foster JL, Garcia JV. Krisko JF, et al. PLoS Pathog. 2013 Mar;9(3):e1003242. doi: 10.1371/journal.ppat.1003242. Epub 2013 Mar 28. PLoS Pathog. 2013. PMID: 23555255 Free PMC article.