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Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ. Thirlwell C, et al. Among authors: jankowski ja. Gastroenterology. 2010 Apr;138(4):1441-54, 1454.e1-7. doi: 10.1053/j.gastro.2010.01.033. Epub 2010 Jan 25. Gastroenterology. 2010. PMID: 20102718
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JA, Turnbull DM, Wright NA, McDonald SA. Greaves LC, et al. Among authors: jankowski ja. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):714-9. doi: 10.1073/pnas.0505903103. Epub 2006 Jan 6. Proc Natl Acad Sci U S A. 2006. PMID: 16407113 Free PMC article.
151 results