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Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.
Gallos G, Yocum GT, Siviski ME, Yim PD, Fu XW, Poe MM, Cook JM, Harrison N, Perez-Zoghbi J, Emala CW Sr. Gallos G, et al. Among authors: yocum gt. Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L931-42. doi: 10.1152/ajplung.00107.2014. Epub 2015 Feb 6. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25659897 Free PMC article.
Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.
Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA. Forkuo GS, et al. Among authors: yocum gt. Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10. Mol Pharm. 2016. PMID: 27120014 Free PMC article.
Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA. Jahan R, et al. Among authors: yocum gt. Eur J Med Chem. 2017 Jan 27;126:550-560. doi: 10.1016/j.ejmech.2016.11.045. Epub 2016 Nov 24. Eur J Med Chem. 2017. PMID: 27915170 Free PMC article.
28 results