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CB1 cannabinoid receptor ligands.
Thakur GA, Nikas SP, Makriyannis A. Thakur GA, et al. Among authors: makriyannis a. Mini Rev Med Chem. 2005 Jul;5(7):631-40. doi: 10.2174/1389557054368772. Mini Rev Med Chem. 2005. PMID: 16026309 Review.
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.
Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A. Picone RP, et al. Among authors: makriyannis a. Mol Pharmacol. 2005 Dec;68(6):1623-35. doi: 10.1124/mol.105.014407. Epub 2005 Sep 12. Mol Pharmacol. 2005. PMID: 16157695
Structural requirements for cannabinoid receptor probes.
Thakur GA, Nikas SP, Li C, Makriyannis A. Thakur GA, et al. Among authors: makriyannis a. Handb Exp Pharmacol. 2005;(168):209-46. doi: 10.1007/3-540-26573-2_7. Handb Exp Pharmacol. 2005. PMID: 16596776 Review.
519 results