Semenza GL - Search Results

1

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.

Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Le A, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. doi: 10.1073/pnas.0914433107. Epub 2010 Jan 19. Proc Natl Acad Sci U S A. 2010. PMID: 20133848 Free PMC article.

2

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Semenza GL, et al. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8725-9. doi: 10.1073/pnas.88.19.8725. Proc Natl Acad Sci U S A. 1991. PMID: 1924331 Free PMC article.

3

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Semenza GL, et al. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5680-4. doi: 10.1073/pnas.88.13.5680. Proc Natl Acad Sci U S A. 1991. PMID: 2062846 Free PMC article.

4

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang GL, Jiang BH, Rue EA, Semenza GL. Wang GL, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4. doi: 10.1073/pnas.92.12.5510. Proc Natl Acad Sci U S A. 1995. PMID: 7539918 Free PMC article.

5

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Wang GL, Semenza GL. Wang GL, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 1993 May 1;90(9):4304-8. doi: 10.1073/pnas.90.9.4304. Proc Natl Acad Sci U S A. 1993. PMID: 8387214 Free PMC article.

6

Oncogenic alterations of metabolism.

Dang CV, Semenza GL. Dang CV, et al. Among authors: semenza gl. Trends Biochem Sci. 1999 Feb;24(2):68-72. doi: 10.1016/s0968-0004(98)01344-9. Trends Biochem Sci. 1999. PMID: 10098401 Free article. Review.

7

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.

Sutter CH, Laughner E, Semenza GL. Sutter CH, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4748-53. doi: 10.1073/pnas.080072497. Proc Natl Acad Sci U S A. 2000. PMID: 10758161 Free PMC article.

8

Hypoxia inhibits G1/S transition through regulation of p27 expression.

Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Gardner LB, et al. Among authors: semenza gl. J Biol Chem. 2001 Mar 16;276(11):7919-26. doi: 10.1074/jbc.M010189200. Epub 2000 Dec 8. J Biol Chem. 2001. PMID: 11112789 Free article.

9

HIF-1 and tumor progression: pathophysiology and therapeutics.

Semenza GL. Semenza GL. Trends Mol Med. 2002;8(4 Suppl):S62-7. doi: 10.1016/s1471-4914(02)02317-1. Trends Mol Med. 2002. PMID: 11927290 Review.

10

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Kim JW, Tchernyshyov I, Semenza GL, Dang CV. Kim JW, et al. Among authors: semenza gl. Cell Metab. 2006 Mar;3(3):177-85. doi: 10.1016/j.cmet.2006.02.002. Cell Metab. 2006. PMID: 16517405 Free article.

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