Seth PP - Search Results

1

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

2

Synthesis and biological activity of 5-fluorotubercidin.

Wang X, Seth PP, Ranken R, Swayze EE, Migawa MT. Wang X, et al. Among authors: seth pp. Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):161-70. doi: 10.1081/ncn-120027825. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15043144

3

Biaryl guanidine inhibitors of in vitro HCV-IRES activity.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Osgood SA, Swayze EE, Risen LM. Jefferson EA, et al. Among authors: seth pp. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5139-43. doi: 10.1016/j.bmcl.2004.07.066. Bioorg Med Chem Lett. 2004. PMID: 15380215

4

Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Risen LM, Osgood SA, Bertrand M, Swayze EE. Jefferson EA, et al. Among authors: seth pp. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5257-61. doi: 10.1016/j.bmcl.2004.08.033. Bioorg Med Chem Lett. 2004. PMID: 15454207

5

Aryl urea analogs with broad-spectrum antibacterial activity.

Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE. Seth PP, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5569-72. doi: 10.1016/j.bmcl.2004.08.059. Bioorg Med Chem Lett. 2004. PMID: 15482926

6

SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain.

Seth PP, Miyaji A, Jefferson EA, Sannes-Lowery KA, Osgood SA, Propp SS, Ranken R, Massire C, Sampath R, Ecker DJ, Swayze EE, Griffey RH. Seth PP, et al. J Med Chem. 2005 Nov 17;48(23):7099-102. doi: 10.1021/jm050815o. J Med Chem. 2005. PMID: 16279767

7

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

8

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

9

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B. Prakash TP, et al. Among authors: seth pp. J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295. J Med Chem. 2010. PMID: 20108935

10

Inhibitor-induced structural change in the HCV IRES domain IIa RNA.

Paulsen RB, Seth PP, Swayze EE, Griffey RH, Skalicky JJ, Cheatham TE 3rd, Davis DR. Paulsen RB, et al. Among authors: seth pp. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7263-8. doi: 10.1073/pnas.0911896107. Epub 2010 Apr 1. Proc Natl Acad Sci U S A. 2010. PMID: 20360559 Free PMC article.

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