Liu M - Search Results

1

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.

Liu M, Dobson B, Glicksman MA, Yue Z, Stein RL. Liu M, et al. Biochemistry. 2010 Mar 9;49(9):2008-17. doi: 10.1021/bi901851y. Biochemistry. 2010. PMID: 20146535 Free PMC article.

2

Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors.

Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Liu M, et al. Biochemistry. 2008 Aug 12;47(32):8367-77. doi: 10.1021/bi800732v. Epub 2008 Jul 18. Biochemistry. 2008. PMID: 18636751

3

Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect.

Liu M, Girma E, Glicksman MA, Stein RL. Liu M, et al. Biochemistry. 2010 Jun 15;49(23):4921-9. doi: 10.1021/bi100244j. Biochemistry. 2010. PMID: 20491486 Free PMC article.

4

Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors.

Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Liu M, et al. Anal Biochem. 2010 Sep 15;404(2):186-92. doi: 10.1016/j.ab.2010.05.033. Epub 2010 Jun 2. Anal Biochem. 2010. PMID: 20566370 Free PMC article.

5

Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.

Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Liu M, et al. Biochemistry. 2011 Nov 1;50(43):9399-408. doi: 10.1021/bi201173d. Epub 2011 Oct 7. Biochemistry. 2011. PMID: 21961647 Free PMC article.

6

Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.

Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Liu M, et al. Biochemistry. 2013 Mar 12;52(10):1725-36. doi: 10.1021/bi3012077. Epub 2013 Mar 1. Biochemistry. 2013. PMID: 23379419 Free PMC article.

7

The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.

Ray S, Bender S, Kang S, Lin R, Glicksman MA, Liu M. Ray S, et al. Among authors: liu m. J Biol Chem. 2014 May 9;289(19):13042-53. doi: 10.1074/jbc.M113.537811. Epub 2014 Apr 2. J Biol Chem. 2014. PMID: 24695735 Free PMC article.

8

New approaches to the discovery of cdk5 inhibitors.

Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. Glicksman MA, et al. Among authors: liu m. Curr Alzheimer Res. 2007 Dec;4(5):547-9. doi: 10.2174/156720507783018181. Curr Alzheimer Res. 2007. PMID: 18220519 Review.

9

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Pytel D, et al. Among authors: liu m. J Biomol Screen. 2014 Aug;19(7):1024-34. doi: 10.1177/1087057114525853. Epub 2014 Mar 5. J Biomol Screen. 2014. PMID: 24598103 Free PMC article.

10

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Among authors: liu m, liu l. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.

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