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Page 1
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Nuti E, Casalini F, Avramova SI, Santamaria S, Fabbi M, Ferrini S, Marinelli L, La Pietra V, Limongelli V, Novellino E, Cercignani G, Orlandini E, Nencetti S, Rossello A. Nuti E, et al. Among authors: casalini f. J Med Chem. 2010 Mar 25;53(6):2622-35. doi: 10.1021/jm901868z. J Med Chem. 2010. PMID: 20180536
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A. Nuti E, et al. Among authors: casalini f. J Med Chem. 2009 Aug 13;52(15):4757-73. doi: 10.1021/jm900261f. J Med Chem. 2009. PMID: 19606871
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D'Amelio N, Maiocchi A, Uggeri F, Rossello A. Nuti E, et al. Among authors: casalini f. J Med Chem. 2009 Oct 22;52(20):6347-61. doi: 10.1021/jm900335a. J Med Chem. 2009. PMID: 19775099
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E, Margarida Bernardo M, Fridman R, Da Settimo F, Martini C, Rossello A. Nuti E, et al. Among authors: casalini f. Eur J Med Chem. 2011 Jul;46(7):2617-29. doi: 10.1016/j.ejmech.2011.03.033. Epub 2011 Apr 2. Eur J Med Chem. 2011. PMID: 21514700 Free PMC article.
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
La Pietra V, Marinelli L, Cosconati S, Di Leva FS, Nuti E, Santamaria S, Pugliesi I, Morelli M, Casalini F, Rossello A, La Motta C, Taliani S, Visse R, Nagase H, da Settimo F, Novellino E. La Pietra V, et al. Among authors: casalini f. Eur J Med Chem. 2012 Jan;47(1):143-52. doi: 10.1016/j.ejmech.2011.10.035. Epub 2011 Oct 25. Eur J Med Chem. 2012. PMID: 22088955
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Da Settimo F, Nagase H, Rossello A. Nuti E, et al. Among authors: casalini f. Eur J Med Chem. 2013 Apr;62:379-94. doi: 10.1016/j.ejmech.2012.12.058. Epub 2013 Jan 11. Eur J Med Chem. 2013. PMID: 23376997
Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.
Casalini F, Fugazza L, Esposito G, Cabella C, Brioschi C, Cordaro A, D'Angeli L, Bartoli A, Filannino AM, Gringeri CV, Longo DL, Muzio V, Nuti E, Orlandini E, Figlia G, Quattrini A, Tei L, Digilio G, Rossello A, Maiocchi A. Casalini F, et al. J Med Chem. 2013 Mar 28;56(6):2676-89. doi: 10.1021/jm4001743. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23458498
15 results