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Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Mazzone M, et al. Among authors: aster jc. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5012-7. doi: 10.1073/pnas.1000896107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194747 Free PMC article.
Notch signaling in leukemia.
Aster JC, Pear WS. Aster JC, et al. Curr Opin Hematol. 2001 Jul;8(4):237-44. doi: 10.1097/00062752-200107000-00010. Curr Opin Hematol. 2001. PMID: 11561162
Notch signaling as a therapeutic target.
Nam Y, Aster JC, Blacklow SC. Nam Y, et al. Among authors: aster jc. Curr Opin Chem Biol. 2002 Aug;6(4):501-9. doi: 10.1016/s1367-5931(02)00346-0. Curr Opin Chem Biol. 2002. PMID: 12133727 Review.
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.
Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Barut B, Freedman M, Lee C, Spitsbergen J, Neuberg D, Weber G, Golub TR, Glickman JN, Kutok JL, Aster JC, Zon LI. Shepard JL, et al. Among authors: aster jc. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13194-9. doi: 10.1073/pnas.0506583102. Epub 2005 Sep 6. Proc Natl Acad Sci U S A. 2005. PMID: 16150706 Free PMC article.
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC. Weng AP, et al. Among authors: aster jc. Genes Dev. 2006 Aug 1;20(15):2096-109. doi: 10.1101/gad.1450406. Epub 2006 Jul 17. Genes Dev. 2006. PMID: 16847353 Free PMC article.
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA. Palomero T, et al. Among authors: aster jc. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. doi: 10.1073/pnas.0606108103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114293 Free PMC article.
298 results