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Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA. Geng H, et al. Among authors: saikumar p. Am J Pathol. 2012 Oct;181(4):1236-49. doi: 10.1016/j.ajpath.2012.06.035. Epub 2012 Aug 10. Am J Pathol. 2012. PMID: 22885106 Free PMC article.
Acute kidney injury: a springboard for progression in chronic kidney disease.
Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK. Venkatachalam MA, et al. Among authors: saikumar p. Am J Physiol Renal Physiol. 2010 May;298(5):F1078-94. doi: 10.1152/ajprenal.00017.2010. Epub 2010 Mar 3. Am J Physiol Renal Physiol. 2010. PMID: 20200097 Free PMC article. Review.
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA. Lan R, et al. Among authors: saikumar p. Am J Physiol Renal Physiol. 2012 May 1;302(9):F1210-23. doi: 10.1152/ajprenal.00660.2011. Epub 2012 Feb 1. Am J Physiol Renal Physiol. 2012. PMID: 22301622 Free PMC article.
59 results