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8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors.
Hudkins RL, Zulli AL, Underiner TL, Angeles TS, Aimone LD, Meyer SL, Pauletti D, Chang H, Fedorov EV, Almo SC, Fedorov AA, Ruggeri BA. Hudkins RL, et al. Among authors: fedorov ev, fedorov aa. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3356-60. doi: 10.1016/j.bmcl.2010.04.021. Epub 2010 Apr 13. Bioorg Med Chem Lett. 2010. PMID: 20430619
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Hudkins RL, Diebold JL, Tao M, Josef KA, Park CH, Angeles TS, Aimone LD, Husten J, Ator MA, Meyer SL, Holskin BP, Durkin JT, Fedorov AA, Fedorov EV, Almo SC, Mathiasen JR, Bozyczko-Coyne D, Saporito MS, Scott RW, Mallamo JP. Hudkins RL, et al. Among authors: fedorov ev, fedorov aa. J Med Chem. 2008 Sep 25;51(18):5680-9. doi: 10.1021/jm8005838. Epub 2008 Aug 21. J Med Chem. 2008. PMID: 18714982
X-ray structure and mutational analysis of the atrazine Chlorohydrolase TrzN.
Seffernick JL, Reynolds E, Fedorov AA, Fedorov E, Almo SC, Sadowsky MJ, Wackett LP. Seffernick JL, et al. Among authors: fedorov aa, fedorov e. J Biol Chem. 2010 Oct 1;285(40):30606-14. doi: 10.1074/jbc.M110.138677. Epub 2010 Jul 20. J Biol Chem. 2010. PMID: 20659898 Free PMC article.
Structure-based activity prediction for an enzyme of unknown function.
Hermann JC, Marti-Arbona R, Fedorov AA, Fedorov E, Almo SC, Shoichet BK, Raushel FM. Hermann JC, et al. Among authors: fedorov aa, fedorov e. Nature. 2007 Aug 16;448(7155):775-9. doi: 10.1038/nature05981. Epub 2007 Jul 1. Nature. 2007. PMID: 17603473 Free PMC article.
285 results