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The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, Antoons G, van Veen TA, Beekman JD, de Groot BL, Opthof T, Rook MB, Vos MA, van der Heyden MA. de Boer TP, et al. Among authors: vos ma. Br J Pharmacol. 2010 Apr;159(7):1532-41. doi: 10.1111/j.1476-5381.2010.00658.x. Epub 2010 Feb 24. Br J Pharmacol. 2010. PMID: 20180941 Free PMC article.
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators. Oros A, et al. Among authors: vos ma. Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x. Br J Pharmacol. 2010. PMID: 20718748 Free PMC article.
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA. Nalos L, et al. Among authors: vos ma. Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x. Br J Pharmacol. 2012. PMID: 21718297 Free PMC article.
298 results