van de Locht A - Search Results

1

Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumor therapies.

Napp J, Dullin C, Müller F, Uhland K, Petri JB, van de Locht A, Steinmetzer T, Alves F. Napp J, et al. Among authors: van de locht a. Int J Cancer. 2010 Oct 15;127(8):1958-74. doi: 10.1002/ijc.25405. Int J Cancer. 2010. PMID: 20473895

2

Use of IHC and newly designed matriptase inhibitors to elucidate the role of matriptase in pancreatic ductal adenocarcinoma.

Uhland K, Siphos B, Arkona C, Schuster M, Petri B, Steinmetzer P, Mueller F, Schweinitz A, Steinmetzer T, Van De Locht A. Uhland K, et al. Among authors: van de locht a. Int J Oncol. 2009 Aug;35(2):347-57. Int J Oncol. 2009. PMID: 19578749

3

Analysis of highly potent amidine containing inhibitors of serine proteases and their N-hydroxylated prodrugs (amidoximes).

Kotthaus J, Steinmetzer T, van de Locht A, Clement B. Kotthaus J, et al. Among authors: van de locht a. J Enzyme Inhib Med Chem. 2011 Feb;26(1):115-22. doi: 10.3109/14756361003733647. Epub 2010 Jun 28. J Enzyme Inhib Med Chem. 2011. PMID: 20583861 Free article.

4

Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase.

Kotthaus J, Steinmetzer T, Kotthaus J, Schade D, van de Locht A, Clement B. Kotthaus J, et al. Among authors: van de locht a. Xenobiotica. 2010 Feb;40(2):93-101. doi: 10.3109/00498250903402266. Xenobiotica. 2010. PMID: 20028195

5

Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery.

Szabó G, Veres G, Radovits T, Haider H, Krieger N, Bährle S, Miesel-Gröschel C, Niklisch S, Karck M, van de Locht A. Szabó G, et al. Among authors: van de locht a. J Thorac Cardiovasc Surg. 2010 Jan;139(1):181-8; discussion 188. doi: 10.1016/j.jtcvs.2009.09.019. J Thorac Cardiovasc Surg. 2010. PMID: 20106364 Free article.

6

The novel synthetic serine protease inhibitor CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model.

Szabó G, Veres G, Radovits T, Haider H, Krieger N, Bährle S, Niklisch S, Miesel-Gröschel C, van de Locht A, Karck M. Szabó G, et al. Among authors: van de locht a. J Thorac Cardiovasc Surg. 2010 Mar;139(3):732-40. doi: 10.1016/j.jtcvs.2009.10.059. J Thorac Cardiovasc Surg. 2010. PMID: 20176215 Free article.

7

CU-2010--a novel small molecule protease inhibitor with antifibrinolytic and anticoagulant properties.

Dietrich W, Nicklisch S, Koster A, Spannagl M, Giersiefen H, van de Locht A. Dietrich W, et al. Among authors: van de locht a. Anesthesiology. 2009 Jan;110(1):123-30. doi: 10.1097/ALN.0b013e318191408c. Anesthesiology. 2009. PMID: 19104179 Free article.

8

The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients.

Kim H, Szlam F, Tanaka KA, van de Locht A, Ogawa S, Levy JH. Kim H, et al. Among authors: van de locht a. Anesth Analg. 2012 Aug;115(2):244-52. doi: 10.1213/ANE.0b013e3182576a5a. Epub 2012 May 14. Anesth Analg. 2012. PMID: 22584552

9

Crystallographic evidence that the F2 kringle catalytic domain linker of prothrombin does not cover the fibrinogen recognition exosite.

van de Locht A, Stubbs MT, Bauer M, Bode W. van de Locht A, et al. J Biol Chem. 1996 Feb 16;271(7):3413-6. doi: 10.1074/jbc.271.7.3413. J Biol Chem. 1996. PMID: 8631941 Free article.

10

Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.

van de Locht A, Lamba D, Bauer M, Huber R, Friedrich T, Kröger B, Höffken W, Bode W. van de Locht A, et al. EMBO J. 1995 Nov 1;14(21):5149-57. doi: 10.1002/j.1460-2075.1995.tb00199.x. EMBO J. 1995. PMID: 7489704 Free PMC article.

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