Cusumano CK - Search Results

1

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW. Han Z, et al. Among authors: cusumano ck. J Med Chem. 2010 Jun 24;53(12):4779-92. doi: 10.1021/jm100438s. J Med Chem. 2010. PMID: 20507142 Free PMC article.

2

Bacterial adhesion--a source of alternate antibiotic targets.

Cusumano CK, Hultgren SJ. Cusumano CK, et al. IDrugs. 2009 Nov;12(11):699-705. IDrugs. 2009. PMID: 19844856 Review.

3

Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding.

Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ. Chen SL, et al. Among authors: cusumano ck. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22439-44. doi: 10.1073/pnas.0902179106. Epub 2009 Dec 16. Proc Natl Acad Sci U S A. 2009. PMID: 20018753 Free PMC article.

4

Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ. Cusumano CK, et al. Sci Transl Med. 2011 Nov 16;3(109):109ra115. doi: 10.1126/scitranslmed.3003021. Sci Transl Med. 2011. PMID: 22089451 Free PMC article.

5

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW. Han Z, et al. Among authors: cusumano ck. J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13. J Med Chem. 2012. PMID: 22449031 Free PMC article.

6

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW. Jarvis C, et al. Among authors: cusumano ck. ChemMedChem. 2016 Feb 17;11(4):367-73. doi: 10.1002/cmdc.201600006. Epub 2016 Jan 26. ChemMedChem. 2016. PMID: 26812660 Free PMC article.

7

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.

Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ. Cegelski L, et al. Among authors: cusumano ck. Nat Chem Biol. 2009 Dec;5(12):913-9. doi: 10.1038/nchembio.242. Epub 2009 Oct 25. Nat Chem Biol. 2009. PMID: 19915538 Free PMC article.

8

Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis.

Cusumano CK, Hung CS, Chen SL, Hultgren SJ. Cusumano CK, et al. Infect Immun. 2010 Apr;78(4):1457-67. doi: 10.1128/IAI.01260-09. Epub 2010 Feb 1. Infect Immun. 2010. PMID: 20123719 Free PMC article.

9

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Kostakioti M, Hadjifrangiskou M, Cusumano CK, Hannan TJ, Janetka JW, Hultgren SJ. Kostakioti M, et al. Among authors: cusumano ck. Infect Immun. 2012 Aug;80(8):2826-34. doi: 10.1128/IAI.00283-12. Epub 2012 Jun 4. Infect Immun. 2012. PMID: 22665375 Free PMC article.

10

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. Guiton PS, et al. Among authors: cusumano ck. Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45. doi: 10.1128/AAC.00447-12. Epub 2012 Jun 25. Antimicrob Agents Chemother. 2012. PMID: 22733070 Free PMC article.

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