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The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.
Lee MH, Atkinson S, Rapti M, Handsley M, Curry V, Edwards D, Murphy G. Lee MH, et al. Among authors: murphy g. Cancer Lett. 2010 Apr 1;290(1):114-22. doi: 10.1016/j.canlet.2009.08.029. Epub 2009 Oct 7. Cancer Lett. 2010. PMID: 19815335
We have previously designed a variant of tissue inhibitor of metalloproteinase (TIMP)-1 bearing a triple mutation (V4A+P6V+T98L, or N-TIMP-1(mt1)) that forms tight binary complex with the soluble catalytic domain of MT1-MMP [M.H. Lee, M. Rapti, G. Murphy, J. Biol. C …
We have previously designed a variant of tissue inhibitor of metalloproteinase (TIMP)-1 bearing a triple mutation (V4A+P6V+T98L, or N-TIMP-1 …
4,219 results