Sagi I - Search Results

1

The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.

Grossman M, Tworowski D, Dym O, Lee MH, Levy Y, Murphy G, Sagi I. Grossman M, et al. Among authors: sagi i. Biochemistry. 2010 Jul 27;49(29):6184-92. doi: 10.1021/bi902141x. Biochemistry. 2010. PMID: 20545310

2

Spectroscopic studies of inhibited alcohol dehydrogenase from Thermoanaerobacter brockii: proposed structure for the catalytic intermediate state.

Kleifeld O, Frenkel A, Bogin O, Eisenstein M, Brumfeld V, Burstein Y, Sagi I. Kleifeld O, et al. Among authors: sagi i. Biochemistry. 2000 Jul 4;39(26):7702-11. doi: 10.1021/bi0002030. Biochemistry. 2000. PMID: 10869175

3

Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.

Kleifeld O, Van den Steen PE, Frenkel A, Cheng F, Jiang HL, Opdenakker G, Sagi I. Kleifeld O, et al. Among authors: sagi i. J Biol Chem. 2000 Nov 3;275(44):34335-43. doi: 10.1074/jbc.M005714200. J Biol Chem. 2000. PMID: 10938090 Free article.

4

X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.

Kleifeld O, Kotra LP, Gervasi DC, Brown S, Bernardo MM, Fridman R, Mobashery S, Sagi I. Kleifeld O, et al. Among authors: sagi i. J Biol Chem. 2001 May 18;276(20):17125-31. doi: 10.1074/jbc.M011604200. Epub 2001 Jan 30. J Biol Chem. 2001. PMID: 11278946 Free article.

5

Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).

Rosenblum G, Meroueh SO, Kleifeld O, Brown S, Singson SP, Fridman R, Mobashery S, Sagi I. Rosenblum G, et al. Among authors: sagi i. J Biol Chem. 2003 Jul 18;278(29):27009-15. doi: 10.1074/jbc.M301139200. Epub 2003 Apr 4. J Biol Chem. 2003. PMID: 12679334 Free article.

6

Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity.

Solomon A, Rosenblum G, Gonzales PE, Leonard JD, Mobashery S, Milla ME, Sagi I. Solomon A, et al. Among authors: sagi i. J Biol Chem. 2004 Jul 23;279(30):31646-54. doi: 10.1074/jbc.M401310200. Epub 2004 Apr 21. J Biol Chem. 2004. PMID: 15102849 Free article.

7

Higher metal-ligand coordination in the catalytic site of cobalt-substituted Thermoanaerobacter brockii alcohol dehydrogenase lowers the barrier for enzyme catalysis.

Kleifeld O, Rulísek L, Bogin O, Frenkel A, Havlas Z, Burstein Y, Sagi I. Kleifeld O, et al. Among authors: sagi i. Biochemistry. 2004 Jun 8;43(22):7151-61. doi: 10.1021/bi0302696. Biochemistry. 2004. PMID: 15170352

8

Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.

Rosenblum G, Meroueh S, Toth M, Fisher JF, Fridman R, Mobashery S, Sagi I. Rosenblum G, et al. Among authors: sagi i. J Am Chem Soc. 2007 Nov 7;129(44):13566-74. doi: 10.1021/ja073941l. Epub 2007 Oct 12. J Am Chem Soc. 2007. PMID: 17929919

9

Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.

Rosenblum G, Van den Steen PE, Cohen SR, Grossmann JG, Frenkel J, Sertchook R, Slack N, Strange RW, Opdenakker G, Sagi I. Rosenblum G, et al. Among authors: sagi i. Structure. 2007 Oct;15(10):1227-36. doi: 10.1016/j.str.2007.07.019. Structure. 2007. PMID: 17937912 Free article.

10

Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme.

Sagi I, Milla ME. Sagi I, et al. Anal Biochem. 2008 Jan 1;372(1):1-10. doi: 10.1016/j.ab.2007.07.037. Epub 2007 Sep 26. Anal Biochem. 2008. PMID: 17963710 Free PMC article. Review.

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