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The Mycobacterium tuberculosis cytochrome P450 system.
Ouellet H, Johnston JB, Ortiz de Montellano PR. Ouellet H, et al. Among authors: johnston jb. Arch Biochem Biophys. 2010 Jan 1;493(1):82-95. doi: 10.1016/j.abb.2009.07.011. Epub 2009 Jul 25. Arch Biochem Biophys. 2010. PMID: 19635450 Free PMC article. Review.
Structural control of cytochrome P450-catalyzed ω-hydroxylation.
Johnston JB, Ouellet H, Podust LM, Ortiz de Montellano PR. Johnston JB, et al. Arch Biochem Biophys. 2011 Mar 1;507(1):86-94. doi: 10.1016/j.abb.2010.08.011. Epub 2010 Aug 19. Arch Biochem Biophys. 2011. PMID: 20727847 Free PMC article. Review.
Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Choy JW, et al. Among authors: johnston jb. Beilstein J Org Chem. 2013;9:15-25. doi: 10.3762/bjoc.9.3. Epub 2013 Jan 4. Beilstein J Org Chem. 2013. PMID: 23400640 Free PMC article.
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. Doyle PS, et al. Among authors: johnston jb. Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385875 Free PMC article.
251 results