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First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ. Linton SD, et al. Among authors: hoglen nc. J Med Chem. 2005 Nov 3;48(22):6779-82. doi: 10.1021/jm050307e. J Med Chem. 2005. PMID: 16250635
Modes of cell death in rat liver after monocrotaline exposure.
Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Copple BL, et al. Among authors: hoglen nc. Toxicol Sci. 2004 Jan;77(1):172-82. doi: 10.1093/toxsci/kfh011. Epub 2003 Nov 4. Toxicol Sci. 2004. PMID: 14600277
17 results