Kaltenbach LS - Search Results

1

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.

Kaltenbach LS, Bolton MM, Shah B, Kanju PM, Lewis GM, Turmel GJ, Whaley JC, Trask OJ Jr, Lo DC. Kaltenbach LS, et al. J Biomol Screen. 2010 Aug;15(7):806-19. doi: 10.1177/1087057110373392. Epub 2010 Jun 25. J Biomol Screen. 2010. PMID: 20581077

2

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay.

Reinhart PH, Kaltenbach LS, Essrich C, Dunn DE, Eudailey JA, DeMarco CT, Turmel GJ, Whaley JC, Wood A, Cho S, Lo DC. Reinhart PH, et al. Among authors: kaltenbach ls. Neurobiol Dis. 2011 Jul;43(1):248-56. doi: 10.1016/j.nbd.2011.03.017. Epub 2011 Mar 31. Neurobiol Dis. 2011. PMID: 21458569 Free PMC article.

3

Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.

Calamini B, Lo DC, Kaltenbach LS. Calamini B, et al. Among authors: kaltenbach ls. Neurotherapeutics. 2013 Jul;10(3):400-15. doi: 10.1007/s13311-013-0195-4. Neurotherapeutics. 2013. PMID: 23700210 Free PMC article.

4

Targeting mutant huntingtin for the development of disease-modifying therapy.

Appl T, Kaltenbach L, Lo DC, Terstappen GC. Appl T, et al. Drug Discov Today. 2012 Nov;17(21-22):1217-23. doi: 10.1016/j.drudis.2012.06.017. Epub 2012 Jul 4. Drug Discov Today. 2012. PMID: 22772050 Review.

5

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.

Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Leyva MJ, et al. Among authors: kaltenbach ls. Chem Biol. 2010 Nov 24;17(11):1189-200. doi: 10.1016/j.chembiol.2010.08.014. Chem Biol. 2010. PMID: 21095569 Free PMC article.

6

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.

Kraft AD, Kaltenbach LS, Lo DC, Harry GJ. Kraft AD, et al. Among authors: kaltenbach ls. Neurobiol Aging. 2012 Mar;33(3):621.e17-33. doi: 10.1016/j.neurobiolaging.2011.02.015. Epub 2011 Apr 11. Neurobiol Aging. 2012. PMID: 21482444 Free PMC article.

7

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.

Baldo B, Paganetti P, Grueninger S, Marcellin D, Kaltenbach LS, Lo DC, Semmelroth M, Zivanovic A, Abramowski D, Smith D, Lotz GP, Bates GP, Weiss A. Baldo B, et al. Among authors: kaltenbach ls. Chem Biol. 2012 Feb 24;19(2):264-75. doi: 10.1016/j.chembiol.2011.12.020. Chem Biol. 2012. PMID: 22365609

8

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.

Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I. Marco S, et al. Among authors: kaltenbach ls. Nat Med. 2013 Aug;19(8):1030-8. doi: 10.1038/nm.3246. Epub 2013 Jul 14. Nat Med. 2013. PMID: 23852340 Free PMC article.

9

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

Van Kanegan MJ, Dunn DE, Kaltenbach LS, Shah B, He DN, McCoy DD, Yang P, Peng J, Shen L, Du L, Cichewicz RH, Newman RA, Lo DC. Van Kanegan MJ, et al. Among authors: kaltenbach ls. Sci Rep. 2016 May 12;6:25626. doi: 10.1038/srep25626. Sci Rep. 2016. PMID: 27172999 Free PMC article.

10

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, Landers JE, Luthi-Carter R, Abagyan R, Dinkova-Kostova AT, Steegborn C, Marsh JL, Lo DC, Thompson LM, Kazantsev AG. Quinti L, et al. Among authors: kaltenbach ls. Cell Chem Biol. 2016 Jul 21;23(7):849-861. doi: 10.1016/j.chembiol.2016.05.015. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427231 Free article.

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