Kew JN - Search Results

1

Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.

Capelli AM, Castelletti L, Salvagno C, Oliosi B, Di Lenarda E, Virginio C, Lightfoot A, Kew JN, Teague S. Capelli AM, et al. Among authors: kew jn. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4561-5. doi: 10.1016/j.bmcl.2010.06.014. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20591663

2

Alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators.

Lightfoot AP, Kew JN, Skidmore J. Lightfoot AP, et al. Among authors: kew jn. Prog Med Chem. 2008;46:131-71. doi: 10.1016/S0079-6468(07)00003-3. Prog Med Chem. 2008. PMID: 18381125 Review. No abstract available.

3

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.

Davies DJ, Crowe M, Lucas N, Quinn J, Miller DD, Pritchard S, Grose D, Bettini E, Calcinaghi N, Virginio C, Abberley L, Goldsmith P, Michel AD, Chessell IP, Kew JN, Miller ND, Gunthorpe MJ. Davies DJ, et al. Among authors: kew jn. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2620-3. doi: 10.1016/j.bmcl.2012.01.108. Epub 2012 Feb 6. Bioorg Med Chem Lett. 2012. PMID: 22366657

4

Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptor.

Mok MH, Kew JN. Mok MH, et al. Among authors: kew jn. J Physiol. 2006 Aug 1;574(Pt 3):699-710. doi: 10.1113/jphysiol.2006.104794. Epub 2006 May 11. J Physiol. 2006. PMID: 16690715 Free PMC article.

5

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Adam G, Wichmann J, Goetschi E, Kew JN, Knoflach F, Mutel V, Gatti S. Woltering TJ, et al. Among authors: kew jn. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1091-5. doi: 10.1016/j.bmcl.2007.12.005. Epub 2007 Dec 8. Bioorg Med Chem Lett. 2008. PMID: 18096387

6

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Wichmann J, Goetschi E, Adam G, Kew JN, Knoflach F, Ballard TM, Huwyler J, Mutel V, Gatti S. Woltering TJ, et al. Among authors: kew jn. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2725-9. doi: 10.1016/j.bmcl.2008.02.076. Epub 2008 Mar 5. Bioorg Med Chem Lett. 2008. PMID: 18374569

7

Reversal of isolation-rearing-induced PPI deficits by an alpha7 nicotinic receptor agonist.

Cilia J, Cluderay JE, Robbins MJ, Reavill C, Southam E, Kew JN, Jones DN. Cilia J, et al. Among authors: kew jn. Psychopharmacology (Berl). 2005 Oct;182(2):214-9. doi: 10.1007/s00213-005-0069-5. Epub 2005 Oct 19. Psychopharmacology (Berl). 2005. PMID: 16001118

8

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels.

Mok MH, Fricker AC, Weil A, Kew JN. Mok MH, et al. Among authors: kew jn. Neuropharmacology. 2009 Sep;57(3):242-9. doi: 10.1016/j.neuropharm.2009.06.003. Epub 2009 Jun 11. Neuropharmacology. 2009. PMID: 19523966

9

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential.

Kew JN. Kew JN. Pharmacol Ther. 2004 Dec;104(3):233-44. doi: 10.1016/j.pharmthera.2004.08.010. Pharmacol Ther. 2004. PMID: 15556676 Review.

10

Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596.

Livingstone PD, Dickinson JA, Srinivasan J, Kew JN, Wonnacott S. Livingstone PD, et al. Among authors: kew jn. J Mol Neurosci. 2010 Jan;40(1-2):172-6. doi: 10.1007/s12031-009-9232-5. Epub 2009 Aug 18. J Mol Neurosci. 2010. PMID: 19688191

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