Kozielski F - Search Results

1

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n. J Med Chem. 2010. PMID: 20597485

2

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.

Kaan HY, Ulaganathan V, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Biochem J. 2009 Dec 14;425(1):55-60. doi: 10.1042/BJ20091207. Biochem J. 2009. PMID: 19793049

3

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2011 Mar 24;54(6):1576-86. doi: 10.1021/jm100991m. Epub 2011 Feb 23. J Med Chem. 2011. PMID: 21344920

4

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F. Wang F, et al. Among authors: kozielski f. J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13. J Med Chem. 2012. PMID: 22248262 Free PMC article.

5

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

Abualhasan MN, Good JA, Wittayanarakul K, Anthony NG, Berretta G, Rath O, Kozielski F, Sutcliffe OB, Mackay SP. Abualhasan MN, et al. Among authors: kozielski f. Eur J Med Chem. 2012 Aug;54:483-98. doi: 10.1016/j.ejmech.2012.05.034. Epub 2012 Jun 7. Eur J Med Chem. 2012. PMID: 22749640

6

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F. Good JA, et al. Among authors: kozielski f. J Med Chem. 2013 Mar 14;56(5):1878-93. doi: 10.1021/jm3014597. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23394180 Free PMC article.

7

"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.

Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS. Kaan HY, et al. Among authors: kozielski f. J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658017 Free PMC article.

8

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

Prokopcová H, Dallinger D, Uray G, Kaan HY, Ulaganathan V, Kozielski F, Laggner C, Kappe CO. Prokopcová H, et al. Among authors: kozielski f. ChemMedChem. 2010 Oct 4;5(10):1760-9. doi: 10.1002/cmdc.201000252. ChemMedChem. 2010. PMID: 20737530

9

The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition.

Kaan HY, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Science. 2011 Aug 12;333(6044):883-5. doi: 10.1126/science.1204824. Science. 2011. PMID: 21836017 Free PMC article.

10

Kinesins and cancer.

Rath O, Kozielski F. Rath O, et al. Among authors: kozielski f. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. doi: 10.1038/nrc3310. Nat Rev Cancer. 2012. PMID: 22825217 Review.

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