Rath O - Search Results

1

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F. Kaan HY, et al. Among authors: rath o. J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n. J Med Chem. 2010. PMID: 20597485

2

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F. Wang F, et al. Among authors: rath o. J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13. J Med Chem. 2012. PMID: 22248262 Free PMC article.

3

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

Abualhasan MN, Good JA, Wittayanarakul K, Anthony NG, Berretta G, Rath O, Kozielski F, Sutcliffe OB, Mackay SP. Abualhasan MN, et al. Among authors: rath o. Eur J Med Chem. 2012 Aug;54:483-98. doi: 10.1016/j.ejmech.2012.05.034. Epub 2012 Jun 7. Eur J Med Chem. 2012. PMID: 22749640

4

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F. Good JA, et al. Among authors: rath o. J Med Chem. 2013 Mar 14;56(5):1878-93. doi: 10.1021/jm3014597. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23394180 Free PMC article.

5

Kinesins and cancer.

Rath O, Kozielski F. Rath O, et al. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. doi: 10.1038/nrc3310. Nat Rev Cancer. 2012. PMID: 22825217 Review.

6

Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.

Ulaganathan V, Talapatra SK, Rath O, Pannifer A, Hackney DD, Kozielski F. Ulaganathan V, et al. Among authors: rath o. J Am Chem Soc. 2013 Feb 13;135(6):2263-72. doi: 10.1021/ja310377d. Epub 2013 Feb 4. J Am Chem Soc. 2013. PMID: 23305346

7

Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.

Talapatra SK, Rath O, Clayton E, Tomasi S, Kozielski F. Talapatra SK, et al. Among authors: rath o. J Nat Prod. 2016 Jun 24;79(6):1576-85. doi: 10.1021/acs.jnatprod.5b00962. Epub 2016 Jun 14. J Nat Prod. 2016. PMID: 27300079

8

Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

Tcherniuk S, Skoufias DA, Labriere C, Rath O, Gueritte F, Guillou C, Kozielski F. Tcherniuk S, et al. Among authors: rath o. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31. doi: 10.1002/anie.201003254. Angew Chem Int Ed Engl. 2010. PMID: 20857469 No abstract available.

9

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich K, Baugh M, Crighton D, Kowalczyk D, Gabrielsen M, Munro J, Croft DR, Lourenco F, James D, Kalna G, McGarry L, Rath O, Shanks E, Garnett MJ, McDermott U, Brookfield J, Charles M, Hammonds T, Olson MF. Mardilovich K, et al. Among authors: rath o. Oncotarget. 2015 Nov 17;6(36):38469-86. doi: 10.18632/oncotarget.6288. Oncotarget. 2015. PMID: 26540348 Free PMC article.

10

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.

von Thun A, Preisinger C, Rath O, Schwarz JP, Ward C, Monsefi N, Rodríguez J, Garcia-Munoz A, Birtwistle M, Bienvenut W, Anderson KI, Kolch W, von Kriegsheim A. von Thun A, et al. Among authors: rath o. Mol Cell Biol. 2013 Nov;33(22):4526-37. doi: 10.1128/MCB.00585-13. Epub 2013 Sep 16. Mol Cell Biol. 2013. PMID: 24043311 Free PMC article.

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