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Design of a disulfide-less, pharmacologically inert, and chemically competent analog of maurocalcine for the efficient transport of impermeant compounds into cells.
Ram N, Weiss N, Texier-Nogues I, Aroui S, Andreotti N, Pirollet F, Ronjat M, Sabatier JM, Darbon H, Jacquemond V, De Waard M. Ram N, et al. Among authors: darbon h. J Biol Chem. 2008 Oct 3;283(40):27048-56. doi: 10.1074/jbc.M804727200. Epub 2008 Jul 11. J Biol Chem. 2008. PMID: 18621738 Free PMC article.
A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.
M'Barek S, Lopez-Gonzalez I, Andreotti N, di Luccio E, Visan V, Grissmer S, Judge S, El Ayeb M, Darbon H, Rochat H, Sampieri F, Béraud E, Fajloun Z, De Waard M, Sabatier JM. M'Barek S, et al. Among authors: darbon h. J Biol Chem. 2003 Aug 15;278(33):31095-104. doi: 10.1074/jbc.M304271200. Epub 2003 Jun 3. J Biol Chem. 2003. PMID: 12783861 Free article.
Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins.
Fajloun Z, Ferrat G, Carlier E, Fathallah M, Lecomte C, Sandoz G, di Luccio E, Mabrouk K, Legros C, Darbon H, Rochat H, Sabatier JM, De Waard M. Fajloun Z, et al. Among authors: darbon h. J Biol Chem. 2000 May 5;275(18):13605-12. doi: 10.1074/jbc.275.18.13605. J Biol Chem. 2000. PMID: 10788477 Free article.
104 results