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A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Ewan K, Pajak B, Stubbs M, Todd H, Barbeau O, Quevedo C, Botfield H, Young R, Ruddle R, Samuel L, Battersby A, Raynaud F, Allen N, Wilson S, Latinkic B, Workman P, McDonald E, Blagg J, Aherne W, Dale T. Ewan K, et al. Among authors: botfield h. Cancer Res. 2010 Jul 15;70(14):5963-73. doi: 10.1158/0008-5472.CAN-10-1028. Epub 2010 Jul 7. Cancer Res. 2010. PMID: 20610623 Free PMC article.
Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension.
Westgate CS, Botfield HF, Alimajstorovic Z, Yiangou A, Walsh M, Smith G, Singhal R, Mitchell JL, Grech O, Markey KA, Hebenstreit D, Tennant DA, Tomlinson JW, Mollan SP, Ludwig C, Akerman I, Lavery GG, Sinclair AJ. Westgate CS, et al. Among authors: botfield hf. JCI Insight. 2021 May 24;6(10):e145346. doi: 10.1172/jci.insight.145346. JCI Insight. 2021. PMID: 33848268 Free PMC article.
A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.
O'Reilly MW, Westgate CS, Hornby C, Botfield H, Taylor AE, Markey K, Mitchell JL, Scotton WJ, Mollan SP, Yiangou A, Jenkinson C, Gilligan LC, Sherlock M, Gibney J, Tomlinson JW, Lavery GG, Hodson DJ, Arlt W, Sinclair AJ. O'Reilly MW, et al. Among authors: botfield h. JCI Insight. 2019 Mar 21;4(6):e125348. doi: 10.1172/jci.insight.125348. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30753168 Free PMC article.
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
Hardy RS, Botfield H, Markey K, Mitchell JL, Alimajstorovic Z, Westgate CSJ, Sagmeister M, Fairclough RJ, Ottridge RS, Yiangou A, Storbeck KH, Taylor AE, Gilligan LC, Arlt W, Stewart PM, Tomlinson JW, Mollan SP, Lavery GG, Sinclair AJ. Hardy RS, et al. Among authors: botfield h. J Clin Endocrinol Metab. 2021 Jan 1;106(1):174-187. doi: 10.1210/clinem/dgaa766. J Clin Endocrinol Metab. 2021. PMID: 33098644 Free PMC article. Clinical Trial.
20 results