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Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors.
Liu H, Kuhn C, Feru F, Jacques SL, Deshmukh GD, Ye P, Rennie GR, Johnson T, Kazmirski S, Low S, Coli R, Ding YH, Cheng AC, Tecle H, English JM, Stanton R, Wu JC. Liu H, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4885-91. doi: 10.1016/j.bmcl.2010.06.073. Epub 2010 Jun 17. Bioorg Med Chem Lett. 2010. PMID: 20620059
Potent and selective thiophene urea-templated inhibitors of S6K.
Ye P, Kuhn C, Juan M, Sharma R, Connolly B, Alton G, Liu H, Stanton R, Kablaoui NM. Ye P, et al. Among authors: liu h. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52. doi: 10.1016/j.bmcl.2010.11.069. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21185721
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.
Tecle H, Feru F, Liu H, Kuhn C, Rennie G, Morris M, Shao J, Cheng AC, Gikunju D, Miret J, Coli R, Xi SH, Clugston SL, Low S, Kazmirski S, Ding YH, Cao Q, Johnson TL, Deshmukh GD, DiNitto JP, Wu JC, English JM. Tecle H, et al. Among authors: liu h. Chem Biol Drug Des. 2009 Dec;74(6):547-59. doi: 10.1111/j.1747-0285.2009.00884.x. Epub 2009 Oct 20. Chem Biol Drug Des. 2009. PMID: 19843080
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Zhong W, Liu H, Kaller MR, Henley C, Magal E, Nguyen T, Osslund TD, Powers D, Rzasa RM, Wang HL, Wang W, Xiong X, Zhang J, Norman MH. Zhong W, et al. Among authors: liu h. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. doi: 10.1016/j.bmcl.2007.07.045. Epub 2007 Aug 6. Bioorg Med Chem Lett. 2007. PMID: 17709247
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