Makley LN - Search Results

1

Bhavsar RB, Makley LN, Tsonis PA. Bhavsar RB, et al. Among authors: makley ln. Hum Genomics. 2010 Jun;4(5):327-44. doi: 10.1186/1479-7364-4-5-327. Hum Genomics. 2010. PMID: 20650820 Free PMC article. Review.

2

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Jaeger AM, et al. Among authors: makley ln. J Biol Chem. 2014 Oct 31;289(44):30459-30469. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204655 Free PMC article.

3

Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions.

Makley LN, Gestwicki JE. Makley LN, et al. Chem Biol Drug Des. 2013 Jan;81(1):22-32. doi: 10.1111/cbdd.12066. Chem Biol Drug Des. 2013. PMID: 23253128 Free PMC article. Review.

4

Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.

Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML. Chafekar SM, et al. Among authors: makley ln. ACS Chem Biol. 2012 Sep 21;7(9):1556-64. doi: 10.1021/cb300166p. Epub 2012 Jun 22. ACS Chem Biol. 2012. PMID: 22709427 Free PMC article.

5

The three cornerstones of chemical biology: innovative probes, new discoveries, and enabling tools.

Thompson AD, Makley LN, McMenimen K, Gestwicki JE. Thompson AD, et al. Among authors: makley ln. ACS Chem Biol. 2012 May 18;7(5):791-6. doi: 10.1021/cb3001827. ACS Chem Biol. 2012. PMID: 22594530 No abstract available.

6

Identification of dihydropyridines that reduce cellular tau levels.

Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Evans CG, et al. Among authors: makley ln. Chem Commun (Camb). 2011 Jan 7;47(1):529-31. doi: 10.1039/c0cc02253e. Epub 2010 Nov 16. Chem Commun (Camb). 2011. PMID: 21082080 Free PMC article.

7

Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.

Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Makley LN, et al. Science. 2015 Nov 6;350(6261):674-7. doi: 10.1126/science.aac9145. Science. 2015. PMID: 26542570 Free PMC article.

8

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: makley ln. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

9

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.

Makley LN, Johnson OT, Ghanakota P, Rauch JN, Osborn D, Wu TS, Cierpicki T, Carlson HA, Gestwicki JE. Makley LN, et al. Bioorg Med Chem. 2021 Mar 15;34:115990. doi: 10.1016/j.bmc.2020.115990. Epub 2021 Jan 24. Bioorg Med Chem. 2021. PMID: 33549906 Free PMC article.

10

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts.

Molnar KS, Dunyak BM, Su B, Izrayelit Y, McGlasson-Naumann B, Hamilton PD, Qian M, Covey DF, Gestwicki JE, Makley LN, Andley UP. Molnar KS, et al. Among authors: makley ln. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3320-3331. doi: 10.1167/iovs.18-25647. Invest Ophthalmol Vis Sci. 2019. PMID: 31369034 Free PMC article.

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