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Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Larocque D, Sanderson NS, Bergeron J, Curtin JF, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokhi C, Pechnick RN, Castro MG, Lowenstein PR. Larocque D, et al. Among authors: wibowo m. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14443-8. doi: 10.1073/pnas.0913496107. Epub 2010 Jul 26. Proc Natl Acad Sci U S A. 2010. PMID: 20660723 Free PMC article.
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Candolfi M, Curtin JF, Yagiz K, Assi H, Wibowo MK, Alzadeh GE, Foulad D, Muhammad AK, Salehi S, Keech N, Puntel M, Liu C, Sanderson NR, Kroeger KM, Dunn R, Martins G, Lowenstein PR, Castro MG. Candolfi M, et al. Among authors: wibowo mk. Neoplasia. 2011 Oct;13(10):947-60. doi: 10.1593/neo.11024. Neoplasia. 2011. PMID: 22028620 Free PMC article.
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Zirger JM, Puntel M, Bergeron J, Wibowo M, Moridzadeh R, Bondale N, Barcia C, Kroeger KM, Liu C, Castro MG, Lowenstein PR. Zirger JM, et al. Among authors: wibowo m. Mol Ther. 2012 Apr;20(4):808-19. doi: 10.1038/mt.2011.243. Epub 2012 Jan 10. Mol Ther. 2012. PMID: 22233583 Free PMC article.
Gene therapy and targeted toxins for glioma.
Castro MG, Candolfi M, Kroeger K, King GD, Curtin JF, Yagiz K, Mineharu Y, Assi H, Wibowo M, Ghulam Muhammad AK, Foulad D, Puntel M, Lowenstein PR. Castro MG, et al. Among authors: wibowo m. Curr Gene Ther. 2011 Jun;11(3):155-80. doi: 10.2174/156652311795684722. Curr Gene Ther. 2011. PMID: 21453286 Free PMC article. Review.
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Candolfi M, Kroeger KM, Xiong W, Liu C, Puntel M, Yagiz K, Muhammad AG, Mineharu Y, Foulad D, Wibowo M, Assi H, Baker GJ, Lowenstein PR, Castro MG. Candolfi M, et al. Among authors: wibowo m. Anticancer Agents Med Chem. 2011 Oct;11(8):729-38. doi: 10.2174/187152011797378689. Anticancer Agents Med Chem. 2011. PMID: 21707497 Free PMC article. Review.
78 results