Humphreys WG - Search Results

1

Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans.

Christopher LJ, Hong H, Vakkalagadda BJ, Clemens PL, Su H, Roongta V, Allentoff A, Sun H, Heller K, Harbison CT, Iyer RA, Humphreys WG, Wong T, Zhang S. Christopher LJ, et al. Among authors: humphreys wg. Drug Metab Dispos. 2010 Nov;38(11):2049-59. doi: 10.1124/dmd.110.034850. Epub 2010 Jul 28. Drug Metab Dispos. 2010. PMID: 20668249 Clinical Trial.

2

Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties.

Humphreys WG, Obermeier MT, Barrish JC, Chong S, Marino AM, Murugesan N, Wang-Iverson D, Morrison RA. Humphreys WG, et al. Xenobiotica. 2003 Nov;33(11):1109-23. doi: 10.1080/00498250310001609147. Xenobiotica. 2003. PMID: 14660175

3

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

Fura A, Shu YZ, Zhu M, Hanson RL, Roongta V, Humphreys WG. Fura A, et al. Among authors: humphreys wg. J Med Chem. 2004 Aug 26;47(18):4339-51. doi: 10.1021/jm040066v. J Med Chem. 2004. PMID: 15317447 Review. No abstract available.

4

In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation.

Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2005 Nov;33(11):1729-39. doi: 10.1124/dmd.105.005447. Epub 2005 Aug 23. Drug Metab Dispos. 2005. PMID: 16118329

5

Structural elucidation of human oxidative metabolites of muraglitazar: use of microbial bioreactors in the biosynthesis of metabolite standards.

Zhang D, Zhang H, Aranibar N, Hanson R, Huang Y, Cheng PT, Wu S, Bonacorsi S, Zhu M, Swaminathan A, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 Feb;34(2):267-80. doi: 10.1124/dmd.105.007153. Epub 2005 Nov 9. Drug Metab Dispos. 2006. PMID: 16280454 Clinical Trial.

6

Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection.

Wang L, Zhang D, Swaminathan A, Xue Y, Cheng PT, Wu S, Mosqueda-Garcia R, Aurang C, Everett DW, Humphreys WG. Wang L, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 Mar;34(3):427-39. doi: 10.1124/dmd.105.007617. Epub 2005 Dec 28. Drug Metab Dispos. 2006. PMID: 16381667

7

Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites.

Li W, Zhang D, Wang L, Zhang H, Cheng PT, Zhang D, Everett DW, Humphreys WG. Li W, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 May;34(5):807-20. doi: 10.1124/dmd.105.007856. Epub 2006 Feb 7. Drug Metab Dispos. 2006. PMID: 16467134

8

Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data.

Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H. Zhu M, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 Oct;34(10):1722-33. doi: 10.1124/dmd.106.009241. Epub 2006 Jun 30. Drug Metab Dispos. 2006. PMID: 16815965

9

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2007 Jan;35(1):150-67. doi: 10.1124/dmd.106.012450. Epub 2006 Oct 24. Drug Metab Dispos. 2007. PMID: 17062777 Clinical Trial.

10

Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.

Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2007 Jan;35(1):139-49. doi: 10.1124/dmd.106.011932. Epub 2006 Oct 24. Drug Metab Dispos. 2007. PMID: 17062778

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