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A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. Miller JP, et al. Among authors: torcassi c. PLoS Genet. 2012;8(11):e1003042. doi: 10.1371/journal.pgen.1003042. Epub 2012 Nov 29. PLoS Genet. 2012. PMID: 23209424 Free PMC article.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE. Kaltenbach LS, et al. Among authors: torcassi c. PLoS Genet. 2007 May 11;3(5):e82. doi: 10.1371/journal.pgen.0030082. PLoS Genet. 2007. PMID: 17500595 Free PMC article.
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Tanaka Y, et al. Among authors: torcassi c. Neurobiol Dis. 2006 Feb;21(2):381-91. doi: 10.1016/j.nbd.2005.07.014. Epub 2005 Sep 16. Neurobiol Dis. 2006. PMID: 16150600