Zhang N - Search Results

1

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.

Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Miller JP, et al. Among authors: zhang n. Neuron. 2010 Jul 29;67(2):199-212. doi: 10.1016/j.neuron.2010.06.021. Neuron. 2010. PMID: 20670829 Free PMC article.

2

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Zhang N, et al. J Biol Chem. 2012 Jun 15;287(25):21204-13. doi: 10.1074/jbc.M111.321661. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511757 Free PMC article.

3

iPSC-based drug screening for Huntington's disease.

Zhang N, Bailus BJ, Ring KL, Ellerby LM. Zhang N, et al. Brain Res. 2016 May 1;1638(Pt A):42-56. doi: 10.1016/j.brainres.2015.09.020. Epub 2015 Sep 30. Brain Res. 2016. PMID: 26428226 Free PMC article. Review.

4

Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.

Zhang N, An MC, Montoro D, Ellerby LM. Zhang N, et al. PLoS Curr. 2010 Oct 28;2:RRN1193. doi: 10.1371/currents.RRN1193. PLoS Curr. 2010. PMID: 21037797 Free PMC article.

5

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.

Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Leyva MJ, et al. Among authors: zhang n. Chem Biol. 2010 Nov 24;17(11):1189-200. doi: 10.1016/j.chembiol.2010.08.014. Chem Biol. 2010. PMID: 21095569 Free PMC article.

6

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. An MC, et al. Among authors: zhang n. Cell Stem Cell. 2012 Aug 3;11(2):253-63. doi: 10.1016/j.stem.2012.04.026. Epub 2012 Jun 28. Cell Stem Cell. 2012. PMID: 22748967 Free PMC article.

7

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

O'Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring KL, Zhang N, Zafar K, Weiss A, Lager B, Schilling B, Gibson BW, Chen S, Kwak S, Ellerby LM. O'Brien R, et al. Among authors: zhang n. J Biol Chem. 2015 Jul 31;290(31):19287-306. doi: 10.1074/jbc.M114.623561. Epub 2015 May 29. J Biol Chem. 2015. PMID: 26025364 Free PMC article.

8

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.

Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. Ring KL, et al. Among authors: zhang n. Stem Cell Reports. 2015 Dec 8;5(6):1023-1038. doi: 10.1016/j.stemcr.2015.11.005. Stem Cell Reports. 2015. PMID: 26651603 Free PMC article.

9

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.

Tousley A, Iuliano M, Weisman E, Sapp E, Zhang N, Vodicka P, Alexander J, Aviolat H, Gatune L, Reeves P, Li X, Khvorova A, Ellerby LM, Aronin N, DiFiglia M, Kegel-Gleason KB. Tousley A, et al. Among authors: zhang n. J Huntingtons Dis. 2019;8(1):53-69. doi: 10.3233/JHD-180311. J Huntingtons Dis. 2019. PMID: 30594931 Free PMC article.

10

Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System.

An MC, O'Brien RN, Zhang N, Patra BN, De La Cruz M, Ray A, Ellerby LM. An MC, et al. Among authors: zhang n. PLoS Curr. 2014 Apr 15;6:ecurrents.hd.0242d2e7ad72225efa72f6964589369a. doi: 10.1371/currents.hd.0242d2e7ad72225efa72f6964589369a. PLoS Curr. 2014. PMID: 24761311 Free PMC article.

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