Negri A - Search Results

1

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening.

Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Zhu J, et al. Among authors: negri a. Blood. 2010 Dec 2;116(23):5050-9. doi: 10.1182/blood-2010-04-281154. Epub 2010 Aug 2. Blood. 2010. PMID: 20679525 Free PMC article.

2

Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.

Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Zhu J, et al. Among authors: negri a. Sci Transl Med. 2012 Mar 14;4(125):125ra32. doi: 10.1126/scitranslmed.3003576. Sci Transl Med. 2012. PMID: 22422993 Free PMC article.

3

Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand.

Negri A, Li J, Naini S, Coller BS, Filizola M. Negri A, et al. J Comput Aided Mol Des. 2012 Sep;26(9):1005-15. doi: 10.1007/s10822-012-9594-6. Epub 2012 Aug 15. J Comput Aided Mol Des. 2012. PMID: 22893377 Free PMC article.

4

Swing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogen.

Cheng M, Li J, Negri A, Coller BS. Cheng M, et al. Among authors: negri a. PLoS One. 2013 Dec 9;8(12):e81609. doi: 10.1371/journal.pone.0081609. eCollection 2013. PLoS One. 2013. PMID: 24349096 Free PMC article.

5

A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.

Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G 3rd, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas CJ. Jiang JK, et al. Among authors: negri a. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53. doi: 10.1016/j.bmcl.2013.12.122. Epub 2014 Jan 8. Bioorg Med Chem Lett. 2014. PMID: 24461295 Free PMC article.

6

Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.

Provasi D, Negri A, Coller BS, Filizola M. Provasi D, et al. Among authors: negri a. Proteins. 2014 Dec;82(12):3231-3240. doi: 10.1002/prot.24540. Epub 2014 Sep 25. Proteins. 2014. PMID: 24677266 Free PMC article.

7

RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.

Li J, Vootukuri S, Shang Y, Negri A, Jiang JK, Nedelman M, Diacovo TG, Filizola M, Thomas CJ, Coller BS. Li J, et al. Among authors: negri a. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2321-9. doi: 10.1161/ATVBAHA.114.303724. Epub 2014 Aug 21. Arterioscler Thromb Vasc Biol. 2014. PMID: 25147334 Free PMC article.

8

αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.

Buitrago L, Rendon A, Liang Y, Simeoni I, Negri A; ThromboGenomics Consortium; Filizola M, Ouwehand WH, Coller BS. Buitrago L, et al. Among authors: negri a. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1898-907. doi: 10.1073/pnas.1422238112. Epub 2015 Mar 31. Proc Natl Acad Sci U S A. 2015. PMID: 25827233 Free PMC article.

9

Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques.

Provasi D, Artacho MC, Negri A, Mobarec JC, Filizola M. Provasi D, et al. Among authors: negri a. PLoS Comput Biol. 2011 Oct;7(10):e1002193. doi: 10.1371/journal.pcbi.1002193. Epub 2011 Oct 13. PLoS Comput Biol. 2011. PMID: 22022248 Free PMC article.

10

Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles.

Scarabelli G, Provasi D, Negri A, Filizola M. Scarabelli G, et al. Among authors: negri a. Biopolymers. 2014 Jan;101(1):21-7. doi: 10.1002/bip.22251. Biopolymers. 2014. PMID: 23564013 Free PMC article.

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