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Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.
Valenza M, Leoni V, Karasinska JM, Petricca L, Fan J, Carroll J, Pouladi MA, Fossale E, Nguyen HP, Riess O, MacDonald M, Wellington C, DiDonato S, Hayden M, Cattaneo E. Valenza M, et al. Among authors: karasinska jm. J Neurosci. 2010 Aug 11;30(32):10844-50. doi: 10.1523/JNEUROSCI.0917-10.2010. J Neurosci. 2010. PMID: 20702713 Free PMC article.
Cholesterol metabolism in Huntington disease.
Karasinska JM, Hayden MR. Karasinska JM, et al. Nat Rev Neurol. 2011 Sep 6;7(10):561-72. doi: 10.1038/nrneurol.2011.132. Nat Rev Neurol. 2011. PMID: 21894212 Review.
ABCA1 influences neuroinflammation and neuronal death.
Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR. Karasinska JM, et al. Neurobiol Dis. 2013 Jun;54:445-55. doi: 10.1016/j.nbd.2013.01.018. Epub 2013 Jan 30. Neurobiol Dis. 2013. PMID: 23376685
45 results