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Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.
Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, Ii M, Agama K, Guo R, Fox D 3rd, Meetei AR, Wilson L, Nguyen H, Weng NP, Brill SJ, Li L, Vindigni A, Pommier Y, Seidman M, Wang W. Xu D, et al. Among authors: thangavel s. EMBO J. 2010 Sep 15;29(18):3140-55. doi: 10.1038/emboj.2010.186. Epub 2010 Aug 13. EMBO J. 2010. PMID: 20711169 Free PMC article.
DNA2 drives processing and restart of reversed replication forks in human cells.
Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A. Thangavel S, et al. J Cell Biol. 2015 Mar 2;208(5):545-62. doi: 10.1083/jcb.201406100. J Cell Biol. 2015. PMID: 25733713 Free PMC article.
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.
Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A. Berti M, et al. Among authors: thangavel s. Nat Struct Mol Biol. 2013 Mar;20(3):347-54. doi: 10.1038/nsmb.2501. Epub 2013 Feb 10. Nat Struct Mol Biol. 2013. PMID: 23396353 Free PMC article.
XLF and H2AX function in series to promote replication fork stability.
Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP. Chen BR, et al. Among authors: thangavel s. J Cell Biol. 2019 Jul 1;218(7):2113-2123. doi: 10.1083/jcb.201808134. Epub 2019 May 23. J Cell Biol. 2019. PMID: 31123184 Free PMC article.
Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.
Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM. Ravi NS, et al. Among authors: thangavel s. Elife. 2022 Feb 11;11:e65421. doi: 10.7554/eLife.65421. Elife. 2022. PMID: 35147495 Free PMC article.
Preferential Expansion of Human CD34+CD133+CD90+ Hematopoietic Stem Cells Enhances Gene-Modified Cell Frequency for Gene Therapy.
Christopher AC, Venkatesan V, Karuppusamy KV, Srinivasan S, Babu P, Azhagiri MKK, Chambayil K, Bagchi A, Rajendiran V, Ravi NS, Kumar S, Marepally SK, Mohankumar KM, Srivastava A, Velayudhan SR, Thangavel S. Christopher AC, et al. Among authors: thangavel s. Hum Gene Ther. 2022 Feb;33(3-4):188-201. doi: 10.1089/hum.2021.089. Epub 2022 Jan 7. Hum Gene Ther. 2022. PMID: 34486377
124 results