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Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.
Rahmani M, Mayo M, Dash R, Sokhi UK, Dmitriev IP, Sarkar D, Dent P, Curiel DT, Fisher PB, Grant S. Rahmani M, et al. Among authors: dent p. Mol Pharmacol. 2010 Dec;78(6):1096-104. doi: 10.1124/mol.110.068007. Epub 2010 Sep 21. Mol Pharmacol. 2010. PMID: 20858700 Free PMC article.
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P, Grant S. Rahmani M, et al. Among authors: dent p. Mol Pharmacol. 2005 Apr;67(4):1166-76. doi: 10.1124/mol.104.007831. Epub 2004 Dec 29. Mol Pharmacol. 2005. PMID: 15625278
The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism.
Dasmahapatra G, Rahmani M, Dent P, Grant S. Dasmahapatra G, et al. Among authors: dent p. Blood. 2006 Jan 1;107(1):232-40. doi: 10.1182/blood-2005-06-2302. Epub 2005 Sep 15. Blood. 2006. Retraction in: Blood. 2019 Jul 4;134(1):95. doi: 10.1182/blood-2019-05-901215 PMID: 16166589 Free PMC article. Retracted.
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Rosato RR, Maggio SC, Almenara JA, Payne SG, Atadja P, Spiegel S, Dent P, Grant S. Rosato RR, et al. Among authors: dent p. Mol Pharmacol. 2006 Jan;69(1):216-25. doi: 10.1124/mol.105.017145. Epub 2005 Sep 27. Mol Pharmacol. 2006. Retraction in: Mol Pharmacol. 2019 Apr;95(4):336. doi: 10.1124/mol.105.017145retraction PMID: 16189296 Retracted.
627 results