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Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, de Angelis MH, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH. Kleinschnitz C, et al. Among authors: schmidt hh. PLoS Biol. 2010 Sep 21;8(9):e1000479. doi: 10.1371/journal.pbio.1000479. PLoS Biol. 2010. PMID: 20877715 Free PMC article.
NOX4 is an early initiator of neuropathic pain.
Geis C, Geuss E, Sommer C, Schmidt HH, Kleinschnitz C. Geis C, et al. Among authors: schmidt hh. Exp Neurol. 2017 Feb;288:94-103. doi: 10.1016/j.expneurol.2016.11.008. Epub 2016 Nov 14. Exp Neurol. 2017. PMID: 27856286
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.
Radermacher KA, Wingler K, Langhauser F, Altenhöfer S, Kleikers P, Hermans JJ, Hrabě de Angelis M, Kleinschnitz C, Schmidt HH. Radermacher KA, et al. Among authors: schmidt hh. Antioxid Redox Signal. 2013 Apr 20;18(12):1418-27. doi: 10.1089/ars.2012.4797. Epub 2012 Oct 16. Antioxid Redox Signal. 2013. PMID: 22937798 Free PMC article. Review.
VAS2870 is a pan-NADPH oxidase inhibitor.
Wingler K, Altenhoefer SA, Kleikers PW, Radermacher KA, Kleinschnitz C, Schmidt HH. Wingler K, et al. Among authors: schmidt hh. Cell Mol Life Sci. 2012 Sep;69(18):3159-60. doi: 10.1007/s00018-012-1107-1. Epub 2012 Aug 9. Cell Mol Life Sci. 2012. PMID: 22875281 Free PMC article. No abstract available.
Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.
Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Jha JC, et al. Among authors: schmidt hh. J Am Soc Nephrol. 2014 Jun;25(6):1237-54. doi: 10.1681/ASN.2013070810. Epub 2014 Feb 7. J Am Soc Nephrol. 2014. PMID: 24511132 Free PMC article.
523 results