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Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates.
Parmar RG, Poslusney M, Busuek M, Williams JM, Garbaccio R, Leander K, Walsh E, Howell B, Sepp-Lorenzino L, Riley S, Patel M, Kemp E, Latham A, Leone A, Soli E, Burke RS, Carr B, Colletti SL, Wang W. Parmar RG, et al. Among authors: burke rs. Bioconjug Chem. 2014 May 21;25(5):896-906. doi: 10.1021/bc400527e. Epub 2014 May 5. Bioconjug Chem. 2014. PMID: 24742200
An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.
Barrett SE, Abrams MT, Burke R, Carr BA, Crocker LS, Garbaccio RM, Howell BJ, Kemp EA, Kowtoniuk RA, Latham AH, Leander KR, Leone AM, Patel M, Pechenov S, Pudvah NT, Riley S, Sepp-Lorenzino L, Walsh ES, Williams JM, Colletti SL. Barrett SE, et al. Int J Pharm. 2014 May 15;466(1-2):58-67. doi: 10.1016/j.ijpharm.2014.03.011. Epub 2014 Mar 5. Int J Pharm. 2014. PMID: 24607208
Abuse of combinations of gabapentin and quetiapine.
Reeves RR, Burke RS. Reeves RR, et al. Among authors: burke rs. Prim Care Companion CNS Disord. 2014 Sep 11;16(5):10.4088/PCC.14l01660. doi: 10.4088/PCC.14l01660. eCollection 2014. Prim Care Companion CNS Disord. 2014. PMID: 25667805 Free PMC article. No abstract available.
siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.
Burke RS, Somasuntharam I, Rearden P, Brown D, Deshmukh SV, DiPietro MA, DiMuzio J, Eisenhandler R, Fauty SE, Gibson C, Gindy ME, Hamilton KA, Knemeyer I, Koeplinger KA, Kwon HW, Lifsted TQ, Menzel K, Patel M, Pudvah N, Rudd DJ, Seitzer J, Strapps WR, Prueksaritanont T, Thompson CD, Hochman JH, Carr BA. Burke RS, et al. Pharm Res. 2014 Dec;31(12):3445-60. doi: 10.1007/s11095-014-1433-0. Epub 2014 Jul 1. Pharm Res. 2014. PMID: 24980206
42 results