Grinnell BW - Search Results

1

Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia.

Schouten M, van 't Veer C, van den Boogaard FE, Gerlitz B, Grinnell BW, Roelofs JJ, Levi M, van der Poll T. Schouten M, et al. Among authors: grinnell bw. J Infect Dis. 2010 Nov 15;202(10):1600-7. doi: 10.1086/656787. Epub 2010 Oct 6. J Infect Dis. 2010. PMID: 20925531

2

Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study.

Schouten M, Sluijs KF, Gerlitz B, Grinnell BW, Roelofs JJ, Levi MM, van 't Veer C, van der Poll T. Schouten M, et al. Among authors: grinnell bw. Crit Care. 2010;14(2):R65. doi: 10.1186/cc8964. Epub 2010 Apr 14. Crit Care. 2010. PMID: 20398279 Free PMC article.

3

Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia.

Schouten M, van 't Veer C, Roelofs JJ, Gerlitz B, Grinnell BW, Levi M, van der Poll T. Schouten M, et al. Among authors: grinnell bw. Thromb Haemost. 2011 Dec;106(6):1189-96. doi: 10.1160/TH11-06-0438. Epub 2011 Sep 8. Thromb Haemost. 2011. PMID: 21901240

4

Antithrombotic efficacy in the guinea pig of a derivative of human protein C with enhanced activation by thrombin.

Kurz KD, Smith T, Wilson A, Gerlitz B, Richardson MA, Grinnell BW. Kurz KD, et al. Among authors: grinnell bw. Blood. 1997 Jan 15;89(2):534-40. Blood. 1997. PMID: 9002956 Free article.

5

Activated protein C modulates chemokine response and tissue injury in experimental sepsis.

Sharma GR, Gerlitz B, Berg DT, Cramer MS, Jakubowski JA, Galbreath EJ, Heuer JG, Grinnell BW. Sharma GR, et al. Among authors: grinnell bw. Adv Exp Med Biol. 2008;614:83-91. doi: 10.1007/978-0-387-74911-2_10. Adv Exp Med Biol. 2008. PMID: 18290317

6

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.

Berg DT, Gerlitz B, Shang J, Smith T, Santa P, Richardson MA, Kurz KD, Grinnell BW, Mace K, Jones BE. Berg DT, et al. Among authors: grinnell bw. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4423-8. doi: 10.1073/pnas.0736918100. Epub 2003 Apr 1. Proc Natl Acad Sci U S A. 2003. PMID: 12671072 Free PMC article.

7

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin.

Glasscock LN, Gerlitz B, Cooper ST, Grinnell BW, Church FC. Glasscock LN, et al. Among authors: grinnell bw. Biochim Biophys Acta. 2003 Jun 26;1649(1):106-17. doi: 10.1016/s1570-9639(03)00164-x. Biochim Biophys Acta. 2003. PMID: 12818196

8

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.

Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW. Gupta A, et al. Among authors: grinnell bw. Am J Physiol Renal Physiol. 2007 Jul;293(1):F245-54. doi: 10.1152/ajprenal.00477.2006. Epub 2007 Apr 4. Am J Physiol Renal Physiol. 2007. PMID: 17409278 Free article.

9

Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response.

Richardson MA, Gupta A, O'Brien LA, Berg DT, Gerlitz B, Syed S, Sharma GR, Cramer MS, Heuer JG, Galbreath EJ, Grinnell BW. Richardson MA, et al. Among authors: grinnell bw. J Pharmacol Exp Ther. 2008 Apr;325(1):17-26. doi: 10.1124/jpet.107.130609. Epub 2008 Jan 8. J Pharmacol Exp Ther. 2008. PMID: 18182560

10

Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin.

Gerlitz B, Grinnell BW. Gerlitz B, et al. Among authors: grinnell bw. J Biol Chem. 1996 Sep 13;271(37):22285-8. doi: 10.1074/jbc.271.37.22285. J Biol Chem. 1996. PMID: 8798383 Free article.

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