Evers R - Search Results

1

The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease.

Monteagudo E, Fonsi M, Chu X, Bleasby K, Evers R, Pucci V, Orsale MV, Cianetti S, Ferrara M, Harper S, Laufer R, Rowley M, Summa V. Monteagudo E, et al. Among authors: evers r. Xenobiotica. 2010 Dec;40(12):826-39. doi: 10.3109/00498254.2010.519061. Epub 2010 Oct 7. Xenobiotica. 2010. PMID: 20925584

2

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition.

Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF, Kulkarni AV, Hafey MJ, Evers R, Johnson JM, Ulrich RG, Slatter JG. Bleasby K, et al. Among authors: evers r. Xenobiotica. 2006 Oct-Nov;36(10-11):963-88. doi: 10.1080/00498250600861751. Xenobiotica. 2006. PMID: 17118916

3

Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.

Tang W, Stearns RA, Chen Q, Bleasby K, Teffera Y, Colletti A, Hafey M, Evers R, Dean DC, Magriotis PA, Lanza TJ, Lin LS, Hagmann WK, Baillie TA. Tang W, et al. Among authors: evers r. Xenobiotica. 2008 Feb;38(2):223-37. doi: 10.1080/00498250701744682. Xenobiotica. 2008. PMID: 18197560

4

Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.

Evers R, Chu XY. Evers R, et al. Mol Pharmacol. 2008 Aug;74(2):309-11. doi: 10.1124/mol.108.048991. Epub 2008 May 20. Mol Pharmacol. 2008. PMID: 18492796 Review.

5

Species differences in drug transporters and implications for translating preclinical findings to humans.

Chu X, Bleasby K, Evers R. Chu X, et al. Among authors: evers r. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):237-52. doi: 10.1517/17425255.2013.741589. Epub 2012 Dec 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23256482 Review.

6

Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions.

Chu X, Chan GH, Evers R. Chu X, et al. Among authors: evers r. J Pharm Sci. 2017 Sep;106(9):2357-2367. doi: 10.1016/j.xphs.2017.04.007. Epub 2017 Apr 14. J Pharm Sci. 2017. PMID: 28416420 Review.

7

Transporters affecting biochemical test results: Creatinine-drug interactions.

Chu X, Bleasby K, Chan GH, Nunes I, Evers R. Chu X, et al. Among authors: evers r. Clin Pharmacol Ther. 2016 Nov;100(5):437-440. doi: 10.1002/cpt.445. Epub 2016 Sep 15. Clin Pharmacol Ther. 2016. PMID: 27509262 Review.

8

Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction.

Hariparsad N, Carr BA, Evers R, Chu X. Hariparsad N, et al. Among authors: evers r. Drug Metab Dispos. 2008 Jun;36(6):1046-55. doi: 10.1124/dmd.108.020677. Epub 2008 Mar 10. Drug Metab Dispos. 2008. PMID: 18332078

9

Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.

Wang L, Prasad B, Salphati L, Chu X, Gupta A, Hop CE, Evers R, Unadkat JD. Wang L, et al. Among authors: evers r. Drug Metab Dispos. 2015 Mar;43(3):367-74. doi: 10.1124/dmd.114.061580. Epub 2014 Dec 22. Drug Metab Dispos. 2015. PMID: 25534768

10

The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

Chu X, Bleasby K, Chan GH, Nunes I, Evers R. Chu X, et al. Among authors: evers r. Drug Metab Dispos. 2016 Sep;44(9):1498-509. doi: 10.1124/dmd.115.067694. Epub 2016 Jan 29. Drug Metab Dispos. 2016. PMID: 26825641 Review.

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